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Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.
Borsoi AF, Alice LM, Sperotto N, Ramos AS, Abbadi BL, Macchi Hopf FS, Silva Dadda AD, Rambo RS, Madeira Silva RB, Paz JD, Pissinate K, Muniz MN, Neves CE, Galina L, González LC, Perelló MA, de Matos Czeczot A, Leyser M, de Oliveira SD, de Araújo Lock G, de Araújo BV, Costa TD, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. Among authors: sperotto n. ACS Med Chem Lett. 2022 Jul 21;13(8):1337-1344. doi: 10.1021/acsmedchemlett.2c00254. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978694 Free PMC article.
New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis.
Giacobbo BC, Pissinate K, Rodrigues-Junior V, Villela AD, Grams ES, Abbadi BL, Subtil FT, Sperotto N, Trindade RV, Back DF, Campos MM, Basso LA, Machado P, Santos DS. Giacobbo BC, et al. Among authors: sperotto n. Eur J Med Chem. 2017 Jan 27;126:491-501. doi: 10.1016/j.ejmech.2016.11.048. Epub 2016 Nov 23. Eur J Med Chem. 2017. PMID: 27914363
1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity.
Macchi FS, Pissinate K, Villela AD, Abbadi BL, Rodrigues-Junior V, Nabinger DD, Altenhofen S, Sperotto N, da Silva Dadda A, Subtil FT, de Freitas TF, Erhart Rauber AP, Borsoi AF, Bonan CD, Bizarro CV, Basso LA, Santos DS, Machado P. Macchi FS, et al. Among authors: sperotto n. Eur J Med Chem. 2018 Jul 15;155:153-164. doi: 10.1016/j.ejmech.2018.06.005. Epub 2018 Jun 2. Eur J Med Chem. 2018. PMID: 29885576
Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolines.
Grams ES, Silva Ramos A, Neves Muniz M, Rambo RS, Alberton Perelló M, Sperotto N, Calle González L, Duarte LS, Galina L, Silva Dadda A, Arraché Gonçalves G, Valim Bizarro C, Basso LA, Machado P. Grams ES, et al. Among authors: sperotto n. Molecules. 2022 Apr 15;27(8):2556. doi: 10.3390/molecules27082556. Molecules. 2022. PMID: 35458755 Free PMC article.
Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles.
Jardim Etchart R, Rambo RS, Lopes Abbadi B, Sperotto N, Ev Neves C, Fries Silva F, Dornelles M, Duarte L, Souza Macchi F, Alberton Perelló M, Vescia Lourega R, Valim Bizarro C, Basso LA, Machado P. Jardim Etchart R, et al. Among authors: sperotto n. Molecules. 2021 Aug 25;26(17):5148. doi: 10.3390/molecules26175148. Molecules. 2021. PMID: 34500579 Free PMC article.
Pre-clinical evaluation of quinoxaline-derived chalcones in tuberculosis.
Muradás TC, Abbadi BL, Villela AD, Macchi FS, Bergo PF, de Freitas TF, Sperotto NDM, Timmers LFSM, Norberto de Souza O, Picada JN, Fachini J, da Silva JB, de Albuquerque NCP, Habenschus MD, Carrão DB, Rocha BA, Barbosa Junior F, de Oliveira ARM, Mascarello A, Neuenfeldf P, Nunes RJ, Morbidoni HR, Campos MM, Basso LA, Rodrigues-Junior VS. Muradás TC, et al. Among authors: sperotto ndm. PLoS One. 2018 Aug 16;13(8):e0202568. doi: 10.1371/journal.pone.0202568. eCollection 2018. PLoS One. 2018. PMID: 30114296 Free PMC article.
25 results