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The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness.
Mus LM, Lambertz I, Claeys S, Kumps C, Van Loocke W, Van Neste C, Umapathy G, Vaapil M, Bartenhagen C, Laureys G, De Wever O, Bexell D, Fischer M, Hallberg B, Schulte J, De Wilde B, Durinck K, Denecker G, De Preter K, Speleman F. Mus LM, et al. Among authors: speleman f. Sci Rep. 2020 Jan 14;10(1):218. doi: 10.1038/s41598-019-57076-5. Sci Rep. 2020. PMID: 31937834 Free PMC article.
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition.
Nunes C, Depestel L, Mus L, Keller KM, Delhaye L, Louwagie A, Rishfi M, Whale A, Kara N, Andrews SR, Dela Cruz F, You D, Siddiquee A, Cologna CT, De Craemer S, Dolman E, Bartenhagen C, De Vloed F, Sanders E, Eggermont A, Bekaert SL, Van Loocke W, Bek JW, Dewyn G, Loontiens S, Van Isterdael G, Decaesteker B, Tilleman L, Van Nieuwerburgh F, Vermeirssen V, Van Neste C, Ghesquiere B, Goossens S, Eyckerman S, De Preter K, Fischer M, Houseley J, Molenaar J, De Wilde B, Roberts SS, Durinck K, Speleman F. Nunes C, et al. Among authors: speleman f. Sci Adv. 2022 Jul 15;8(28):eabn1382. doi: 10.1126/sciadv.abn1382. Epub 2022 Jul 13. Sci Adv. 2022. PMID: 35857500 Free PMC article.
SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry.
Decaesteker B, Louwagie A, Loontiens S, De Vloed F, Bekaert SL, Roels J, Vanhauwaert S, De Brouwer S, Sanders E, Berezovskaya A, Denecker G, D'haene E, Van Haver S, Van Loocke W, Van Dorpe J, Creytens D, Van Roy N, Pieters T, Van Neste C, Fischer M, Van Vlierberghe P, Roberts SS, Schulte J, Ek S, Versteeg R, Koster J, van Nes J, Zimmerman M, De Preter K, Speleman F. Decaesteker B, et al. Among authors: speleman f. Nat Commun. 2023 Mar 7;14(1):1267. doi: 10.1038/s41467-023-36735-2. Nat Commun. 2023. PMID: 36882421 Free PMC article.
Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma.
Van Haver S, Fan Y, Bekaert SL, Everaert C, Van Loocke W, Zanzani V, Deschildre J, Maestre IF, Amaro A, Vermeirssen V, De Preter K, Zhou T, Kentsis A, Studer L, Speleman F, Roberts SS. Van Haver S, et al. Among authors: speleman f. iScience. 2023 Sep 30;27(1):108096. doi: 10.1016/j.isci.2023.108096. eCollection 2024 Jan 19. iScience. 2023. PMID: 38222111 Free PMC article.
Cellular senescence in neuroblastoma.
Zanotti S, Decaesteker B, Vanhauwaert S, De Wilde B, De Vos WH, Speleman F. Zanotti S, et al. Among authors: speleman f. Br J Cancer. 2022 Jun;126(11):1529-1538. doi: 10.1038/s41416-022-01755-0. Epub 2022 Feb 23. Br J Cancer. 2022. PMID: 35197583 Free PMC article. Review.
High resolution tiling-path BAC array deletion mapping suggests commonly involved 3p21-p22 tumor suppressor genes in neuroblastoma and more frequent tumors.
Hoebeeck J, Michels E, Menten B, Van Roy N, Eggert A, Schramm A, De Preter K, Yigit N, De Smet E, De Paepe A, Laureys G, Vandesompele J, Speleman F. Hoebeeck J, et al. Among authors: speleman f. Int J Cancer. 2007 Feb 1;120(3):533-8. doi: 10.1002/ijc.22326. Int J Cancer. 2007. PMID: 17096344 Free article.
Aberrant methylation of candidate tumor suppressor genes in neuroblastoma.
Hoebeeck J, Michels E, Pattyn F, Combaret V, Vermeulen J, Yigit N, Hoyoux C, Laureys G, De Paepe A, Speleman F, Vandesompele J. Hoebeeck J, et al. Among authors: speleman f. Cancer Lett. 2009 Jan 18;273(2):336-46. doi: 10.1016/j.canlet.2008.08.019. Epub 2008 Sep 25. Cancer Lett. 2009. PMID: 18819746
410 results