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Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Bassani-Sternberg M, Bräunlein E, Klar R, Engleitner T, Sinitcyn P, Audehm S, Straub M, Weber J, Slotta-Huspenina J, Specht K, Martignoni ME, Werner A, Hein R, H Busch D, Peschel C, Rad R, Cox J, Mann M, Krackhardt AM. Bassani-Sternberg M, et al. Among authors: specht k. Nat Commun. 2016 Nov 21;7:13404. doi: 10.1038/ncomms13404. Nat Commun. 2016. PMID: 27869121 Free PMC article.
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency.
Kovac M, Blattmann C, Ribi S, Smida J, Mueller NS, Engert F, Castro-Giner F, Weischenfeldt J, Kovacova M, Krieg A, Andreou D, Tunn PU, Dürr HR, Rechl H, Schaser KD, Melcher I, Burdach S, Kulozik A, Specht K, Heinimann K, Fulda S, Bielack S, Jundt G, Tomlinson I, Korbel JO, Nathrath M, Baumhoer D. Kovac M, et al. Among authors: specht k. Nat Commun. 2015 Dec 3;6:8940. doi: 10.1038/ncomms9940. Nat Commun. 2015. PMID: 26632267 Free PMC article.
Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma.
Chudasama P, Renner M, Straub M, Mughal SS, Hutter B, Kosaloglu Z, Schweßinger R, Scheffler M, Alldinger I, Schimmack S, Persigehl T, Kobe C, Jäger D, von Kalle C, Schirmacher P, Beckhaus MK, Wolf S, Heining C, Gröschel S, Wolf J, Brors B, Weichert W, Glimm H, Scholl C, Mechtersheimer G, Specht K, Fröhling S. Chudasama P, et al. Among authors: specht k. Clin Cancer Res. 2017 Feb 15;23(4):962-973. doi: 10.1158/1078-0432.CCR-16-0860. Epub 2016 Aug 17. Clin Cancer Res. 2017. PMID: 27535980
A Novel Grading System Based on Tumor Budding and Cell Nest Size Is a Strong Predictor of Patient Outcome in Esophageal Squamous Cell Carcinoma.
Jesinghaus M, Boxberg M, Konukiewitz B, Slotta-Huspenina J, Schlitter AM, Steiger K, Specht K, Wieczorek K, Warth A, Schmidt T, Hartmann A, Demir IE, Feith M, Ott K, Weichert W. Jesinghaus M, et al. Among authors: specht k. Am J Surg Pathol. 2017 Aug;41(8):1112-1120. doi: 10.1097/PAS.0000000000000865. Am J Surg Pathol. 2017. PMID: 28505009
Increased intraepithelial CD3+ T-lymphocytes and high PD-L1 expression on tumor cells are associated with a favorable prognosis in esophageal squamous cell carcinoma and allow prognostic immunogenic subgrouping.
Jesinghaus M, Steiger K, Slotta-Huspenina J, Drecoll E, Pfarr N, Meyer P, Konukiewitz B, Bettstetter M, Wieczorek K, Ott K, Feith M, Langer R, Weichert W, Specht K, Boxberg M. Jesinghaus M, et al. Among authors: specht k. Oncotarget. 2017 Jul 18;8(29):46756-46768. doi: 10.18632/oncotarget.18606. Oncotarget. 2017. PMID: 28657901 Free PMC article.
Proteomic Characterization of Undifferentiated Small Round Cell Sarcomas with EWSR1- and CIC::DUX4-Translocations Reveals Diverging Tumor Biology and Distinct Diagnostic Markers.
Doll S, Schweizer L, Bollwein C, Steiger K, Pfarr N, Walker M, Wörtler K, Knebel C, von Eisenhart-Rothe R, Hartmann W, Weichert W, Mann M, Kuhn PH, Specht K. Doll S, et al. Among authors: specht k. Mod Pathol. 2024 May 3:100511. doi: 10.1016/j.modpat.2024.100511. Online ahead of print. Mod Pathol. 2024. PMID: 38705279
Cyclin D1 positive multiple myeloma: predominance of the short, 3'UTR-deficient transcript is associated with high cyclin D1 mRNA levels in cases with t(11;14) translocation, but does not correlate with proliferation rate or genomic deletions.
Slotta-Huspenina J, Koch I, Richter M, Bink K, Kremer M, Specht K, Krugmann J, Quintanilla-Martinez L, Fend F. Slotta-Huspenina J, et al. Among authors: specht k. Leuk Res. 2008 Jan;32(1):79-88. doi: 10.1016/j.leukres.2007.05.021. Epub 2007 Jul 16. Leuk Res. 2008. PMID: 17629555
Detection of mutant free circulating tumor DNA in the plasma of patients with gastrointestinal stromal tumor harboring activating mutations of CKIT or PDGFRA.
Maier J, Lange T, Kerle I, Specht K, Bruegel M, Wickenhauser C, Jost P, Niederwieser D, Peschel C, Duyster J, von Bubnoff N. Maier J, et al. Among authors: specht k. Clin Cancer Res. 2013 Sep 1;19(17):4854-67. doi: 10.1158/1078-0432.CCR-13-0765. Epub 2013 Jul 5. Clin Cancer Res. 2013. PMID: 23833305 Clinical Trial.
296 results