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Page 1
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Among authors: speake m. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857
A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing.
Pandarakalam GC, Speake M, McElroy S, Alturkistani A, Philippe L, Pettitt J, Müller B, Connolly B. Pandarakalam GC, et al. Among authors: speake m. Int J Parasitol Drugs Drug Resist. 2019 Aug;10:28-37. doi: 10.1016/j.ijpddr.2019.04.001. Epub 2019 Apr 5. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31015150 Free PMC article.
Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist.
Brown AR, Bosies M, Cameron H, Clark J, Cowley A, Craighead M, Elmore MA, Firth A, Goodwin R, Goutcher S, Grant E, Grassie M, Grove SJ, Hamilton NM, Hampson H, Hillier A, Ho KK, Kiczun M, Kingsbury C, Kultgen SG, Littlewood PT, Lusher SJ, Macdonald S, McIntosh L, McIntyre T, Mistry A, Morphy JR, Nimz O, Ohlmeyer M, Pick J, Rankovic Z, Sherborne B, Smith A, Speake M, Spinks G, Thomson F, Watson L, Weston M. Brown AR, et al. Among authors: speake m. Bioorg Med Chem Lett. 2011 Jan 1;21(1):137-40. doi: 10.1016/j.bmcl.2010.11.054. Epub 2010 Nov 16. Bioorg Med Chem Lett. 2011. PMID: 21129964
Discovery and characterization of novel TRPML1 agonists.
Peng X, Holler CJ, Alves AF, Oliviera MG, Speake M, Pugliese A, Oskouei MR, de Freitas ID, Chen AY, Gallegos R, McTighe SM, Koenig G, Hurst RS, Blain JF, Lanter JC, Burnett DA. Peng X, et al. Among authors: speake m. Bioorg Med Chem Lett. 2024 Jan 15;98:129595. doi: 10.1016/j.bmcl.2023.129595. Epub 2023 Dec 22. Bioorg Med Chem Lett. 2024. PMID: 38141860
Tacrolimus monotherapy in renal transplantation: four-year data.
Coupes BM, Speake M, Johnson RW, Roberts IS, Campbell B, Short CD. Coupes BM, et al. Among authors: speake m. Transplant Proc. 2002 Aug;34(5):1612-3. doi: 10.1016/s0041-1345(02)03043-9. Transplant Proc. 2002. PMID: 12176506 No abstract available.