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Lack of support for bexarotene as a treatment for Alzheimer's disease.
O'Hare E, Jeggo R, Kim EM, Barbour B, Walczak JS, Palmer P, Lyons T, Page D, Hanna D, Meara JR, Spanswick D, Guo JP, McGeer EG, McGeer PL, Hobson P. O'Hare E, et al. Among authors: spanswick d. Neuropharmacology. 2016 Jan;100:124-30. doi: 10.1016/j.neuropharm.2015.04.020. Epub 2015 May 27. Neuropharmacology. 2016. PMID: 26025659 Free article.
MRZ-99030 - A novel modulator of Aβ aggregation: II - Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice.
Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka-Saidi K, Jeggo R, Staniaszek L, Spanswick D, O'Hare E, Palmer P, Kim EM, Bywalez W, Egger V, Parsons CG. Rammes G, et al. Among authors: spanswick d. Neuropharmacology. 2015 May;92:170-82. doi: 10.1016/j.neuropharm.2014.12.037. Epub 2015 Jan 28. Neuropharmacology. 2015. PMID: 25637092
Orally bioavailable small molecule drug protects memory in Alzheimer's disease models.
O'Hare E, Scopes DI, Kim EM, Palmer P, Jones M, Whyment AD, Spanswick D, Amijee H, Nerou E, McMahon B, Treherne JM, Jeggo R. O'Hare E, et al. Among authors: spanswick d. Neurobiol Aging. 2013 Apr;34(4):1116-25. doi: 10.1016/j.neurobiolaging.2012.10.016. Epub 2012 Nov 17. Neurobiol Aging. 2013. PMID: 23164690
75 results