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Efficacy of the treatment using a microemulsion loaded with epoxy-α-lapachone in combination with meglumine antimoniate against murine infection by Leishmania (Leishmania) amazonensis.
Peixoto JF, Gonçalves-Oliveira LF, Souza-Silva F, de Castro Côrtes LM, Finkelstein LC, Dias-Lopes G, Patricio BFC, Lima CGS, Rocha HVA, da Silva FC, Ferreira VF, Pereira BAS, Alves CR. Peixoto JF, et al. Among authors: souza silva f. Int J Parasitol Drugs Drug Resist. 2024 Apr;24:100525. doi: 10.1016/j.ijpddr.2024.100525. Epub 2024 Feb 9. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38359731 Free PMC article.
The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis.
Gonçalves-Oliveira LF, Souza-Silva F, de Castro Côrtes LM, Veloso LB, Santini Pereira BA, Cysne-Finkelstein L, Lechuga GC, Bourguignon SC, Almeida-Souza F, da Silva Calabrese K, Ferreira VF, Alves CR. Gonçalves-Oliveira LF, et al. Int J Parasitol Drugs Drug Resist. 2019 Aug;10:101-108. doi: 10.1016/j.ijpddr.2019.08.002. Epub 2019 Aug 12. Int J Parasitol Drugs Drug Resist. 2019. PMID: 31430693 Free PMC article.
Development of a microemulsion loaded with epoxy-α-lapachone against Leishmania (Leishmania) amazonensis murine infection.
Peixoto JF, Gonçalves-Oliveira LF, Souza-Silva F, Côrtes LMC, Dias-Lopes G, Cardoso FO, Santos RO, Patricio BFC, Nicoletti CD, Lima CGS, Calabrese KDS, Moreira DL, Rocha HVA, da Silva FC, Ferreira VF, Alves CR. Peixoto JF, et al. Among authors: souza silva f. Int J Pharm. 2023 Apr 5;636:122864. doi: 10.1016/j.ijpharm.2023.122864. Epub 2023 Mar 17. Int J Pharm. 2023. PMID: 36934883
Epoxy-α-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite.
Souza-Silva F, Bourguignon SC, Pereira BA, Côrtes LM, de Oliveira LF, Henriques-Pons A, Finkelstein LC, Ferreira VF, Carneiro PF, de Pinho RT, Caffarena ER, Alves CR. Souza-Silva F, et al. Antimicrob Agents Chemother. 2015 Apr;59(4):1910-8. doi: 10.1128/AAC.04742-14. Epub 2015 Jan 12. Antimicrob Agents Chemother. 2015. PMID: 25583728 Free PMC article.
Exploring the Association of Surface Plasmon Resonance with Recombinant MHC:Ig Hybrid Protein as a Tool for Detecting T Lymphocytes in Mice Infected with Leishmania (Leishmania) amazonensis.
da Silveira-Júnior LS, Souza-Silva F, Pereira BA, Cysne-Finkelstein L, Cavalcanti Júnior GB, Alves CR. da Silveira-Júnior LS, et al. Biomed Res Int. 2017;2017:9089748. doi: 10.1155/2017/9089748. Epub 2017 Mar 8. Biomed Res Int. 2017. PMID: 28373990 Free PMC article.
Antileishmanial Activity of 2-Methoxy-4H-spiro-[naphthalene-1,2'-oxiran]-4-one (Epoxymethoxy-lawsone): A Promising New Drug Candidate for Leishmaniasis Treatment.
Oliveira LFG, Souza-Silva F, de Castro Côrtes LM, Cysne-Finkelstein L, de Souza Pereira MC, de Oliveira Junior FO, Pinho RT, Corte Real S, Bourguignon SC, Ferreira VF, Alves CR. Oliveira LFG, et al. Molecules. 2018 Apr 10;23(4):864. doi: 10.3390/molecules23040864. Molecules. 2018. PMID: 29642584 Free PMC article.
41 results