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Efficient synthesis of 16 aromatic Morita-Baylis-Hillman adducts: Biological evaluation on Leishmania amazonensis and Leishmania chagasi.
Junior CG, de Assis PA, Silva FP, Sousa SC, de Andrade NG, Barbosa TP, Nerís PL, Segundo LV, Anjos IC, Carvalho GA, Rocha GB, Oliveira MR, Vasconcellos ML. Junior CG, et al. Among authors: sousa sc. Bioorg Chem. 2010 Dec;38(6):279-84. doi: 10.1016/j.bioorg.2010.08.002. Epub 2010 Sep 19. Bioorg Chem. 2010. PMID: 20855101
Morita-Baylis-Hillman adduct shows in vitro activity against Leishmania (Viannia) braziliensis associated with a reduction in IL-6 and IL-10 but independent of nitric oxide.
Amorim FM, Rodrigues YK, Barbosa TP, Néris PL, Caldas JP, Sousa SC, Leite JA, Rodrigues-Mascarenhas S, Vasconcellos ML, Oliveira MR. Amorim FM, et al. Among authors: sousa sc. Parasitology. 2013 Jan;140(1):29-38. doi: 10.1017/S0031182012001291. Epub 2012 Aug 20. Parasitology. 2013. PMID: 22906971
121 results