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Unusual dimeric flavonoids (brachydins) induce ultrastructural membrane alterations associated with antitumor activity in cancer cell lines.
Maciel-Silva VL, da Rocha CQ, Alencar LMR, Castelo-Branco PV, Sousa IH, Azevedo-Santos AP, Vale AAM, Monteiro SG, Soares RP, Guimarães SJA, Nascimento JRD, Pereira SRF. Maciel-Silva VL, et al. Among authors: sousa ih. Drug Chem Toxicol. 2023 Nov;46(4):665-676. doi: 10.1080/01480545.2022.2080217. Epub 2022 May 29. Drug Chem Toxicol. 2023. PMID: 35635136
Ruthenium (II) complexes with N, O-chelating proline and threonine ligands cause selective cytotoxicity by the induction of genomic instability, cell cycle arrest and apoptosis in breast and prostate tumor cells.
de Sousa IH, Campos VNS, Vale AAM, Maciel-Silva VL, Leite CM, Lopes AJO, Mourão PS, das Chagas Alves Lima F, Batista AA, de Azevedo Dos Santos APS, Almeida MAP, Pereira SRF. de Sousa IH, et al. Toxicol In Vitro. 2020 Feb;62:104679. doi: 10.1016/j.tiv.2019.104679. Epub 2019 Oct 30. Toxicol In Vitro. 2020. PMID: 31676337