Sourimant J - Search Results

1

Viral evolution identifies a regulatory interface between paramyxovirus polymerase complex and nucleocapsid that controls replication dynamics.

Sourimant J, Thakkar VD, Cox RM, Plemper RK. Sourimant J, et al. Sci Adv. 2020 Mar 4;6(10):eaaz1590. doi: 10.1126/sciadv.aaz1590. eCollection 2020 Mar. Sci Adv. 2020. PMID: 32181359 Free PMC article.

2

Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex.

Sourimant J, Plemper RK. Sourimant J, et al. Viruses. 2016 Sep 10;8(9):251. doi: 10.3390/v8090251. Viruses. 2016. PMID: 27626440 Free PMC article. Review.

3

The Unstructured Paramyxovirus Nucleocapsid Protein Tail Domain Modulates Viral Pathogenesis through Regulation of Transcriptase Activity.

Thakkar VD, Cox RM, Sawatsky B, da Fontoura Budaszewski R, Sourimant J, Wabbel K, Makhsous N, Greninger AL, von Messling V, Plemper RK. Thakkar VD, et al. Among authors: sourimant j. J Virol. 2018 Mar 28;92(8):e02064-17. doi: 10.1128/JVI.02064-17. Print 2018 Apr 15. J Virol. 2018. PMID: 29437959 Free PMC article.

4

Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.

Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK. Cox RM, et al. Among authors: sourimant j. J Biol Chem. 2018 Oct 26;293(43):16761-16777. doi: 10.1074/jbc.RA118.004862. Epub 2018 Sep 11. J Biol Chem. 2018. PMID: 30206124 Free PMC article.

5

Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner.

Edwards MR, Liu G, De S, Sourimant J, Pietzsch C, Johnson B, Amarasinghe GK, Leung DW, Bukreyev A, Plemper RK, Aron Z, Bowlin TL, Moir DT, Basler CF. Edwards MR, et al. Among authors: sourimant j. ACS Infect Dis. 2020 Mar 13;6(3):489-502. doi: 10.1021/acsinfecdis.9b00416. Epub 2020 Jan 15. ACS Infect Dis. 2020. PMID: 31899866 Free PMC article.

6

Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus.

Pribut N, Kaiser TM, Wilson RJ, Jecs E, Dentmon ZW, Pelly SC, Sharma S, Bartsch PW 3rd, Burger PB, Hwang SS, Le T, Sourimant J, Yoon JJ, Plemper RK, Liotta DC. Pribut N, et al. Among authors: sourimant j. ACS Infect Dis. 2020 May 8;6(5):922-929. doi: 10.1021/acsinfecdis.9b00524. Epub 2020 Apr 20. ACS Infect Dis. 2020. PMID: 32275393 Free PMC article.

7

Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase.

Cox RM, Sourimant J, Toots M, Yoon JJ, Ikegame S, Govindarajan M, Watkinson RE, Thibault P, Makhsous N, Lin MJ, Marengo JR, Sticher Z, Kolykhalov AA, Natchus MG, Greninger AL, Lee B, Plemper RK. Cox RM, et al. Among authors: sourimant j. Nat Microbiol. 2020 Oct;5(10):1232-1246. doi: 10.1038/s41564-020-0752-7. Epub 2020 Jul 13. Nat Microbiol. 2020. PMID: 32661315 Free PMC article.

8

High-Throughput Screening Assay to Identify Small Molecule Inhibitors of Marburg Virus VP40 Protein.

Luthra P, Anantpadma M, De S, Sourimant J, Davey RA, Plemper RK, Basler CF. Luthra P, et al. Among authors: sourimant j. ACS Infect Dis. 2020 Oct 9;6(10):2783-2799. doi: 10.1021/acsinfecdis.0c00512. Epub 2020 Sep 16. ACS Infect Dis. 2020. PMID: 32870648 Free PMC article.

9

Therapeutic targeting of measles virus polymerase with ERDRP-0519 suppresses all RNA synthesis activity.

Cox RM, Sourimant J, Govindarajan M, Natchus MG, Plemper RK. Cox RM, et al. Among authors: sourimant j. PLoS Pathog. 2021 Feb 23;17(2):e1009371. doi: 10.1371/journal.ppat.1009371. eCollection 2021 Feb. PLoS Pathog. 2021. PMID: 33621266 Free PMC article.

10

Progress and pitfalls of a year of drug repurposing screens against COVID-19.

Sourimant J, Aggarwal M, Plemper RK. Sourimant J, et al. Curr Opin Virol. 2021 Aug;49:183-193. doi: 10.1016/j.coviro.2021.06.004. Epub 2021 Jun 19. Curr Opin Virol. 2021. PMID: 34218010 Free PMC article. Review.

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