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MYC targeting by OMO-103 in solid tumors: a phase 1 trial.
Garralda E, Beaulieu ME, Moreno V, Casacuberta-Serra S, Martínez-Martín S, Foradada L, Alonso G, Massó-Vallés D, López-Estévez S, Jauset T, Corral de la Fuente E, Doger B, Hernández T, Perez-Lopez R, Arqués O, Castillo Cano V, Morales J, Whitfield JR, Niewel M, Soucek L, Calvo E. Garralda E, et al. Among authors: soucek l. Nat Med. 2024 Mar;30(3):762-771. doi: 10.1038/s41591-024-02805-1. Epub 2024 Feb 6. Nat Med. 2024. PMID: 38321218 Free PMC article. Clinical Trial.
Tumor microenvironment: becoming sick of Myc.
Whitfield JR, Soucek L. Whitfield JR, et al. Among authors: soucek l. Cell Mol Life Sci. 2012 Mar;69(6):931-4. doi: 10.1007/s00018-011-0860-x. Epub 2011 Oct 28. Cell Mol Life Sci. 2012. PMID: 22033838 Free PMC article. Review.
Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis.
Annibali D, Whitfield JR, Favuzzi E, Jauset T, Serrano E, Cuartas I, Redondo-Campos S, Folch G, Gonzàlez-Juncà A, Sodir NM, Massó-Vallés D, Beaulieu ME, Swigart LB, Mc Gee MM, Somma MP, Nasi S, Seoane J, Evan GI, Soucek L. Annibali D, et al. Among authors: soucek l. Nat Commun. 2014 Aug 18;5:4632. doi: 10.1038/ncomms5632. Nat Commun. 2014. PMID: 25130259 Free PMC article.
Ibrutinib repurposing: from B-cell malignancies to solid tumors.
Massó-Vallés D, Jauset T, Soucek L. Massó-Vallés D, et al. Among authors: soucek l. Oncoscience. 2016 Jun 10;3(5-6):147-8. doi: 10.18632/oncoscience.310. eCollection 2016. Oncoscience. 2016. PMID: 27489860 Free PMC article. No abstract available.
Strategies to Inhibit Myc and Their Clinical Applicability.
Whitfield JR, Beaulieu ME, Soucek L. Whitfield JR, et al. Among authors: soucek l. Front Cell Dev Biol. 2017 Feb 23;5:10. doi: 10.3389/fcell.2017.00010. eCollection 2017. Front Cell Dev Biol. 2017. PMID: 28280720 Free PMC article. Review.
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy.
Beaulieu ME, Jauset T, Massó-Vallés D, Martínez-Martín S, Rahl P, Maltais L, Zacarias-Fluck MF, Casacuberta-Serra S, Serrano Del Pozo E, Fiore C, Foradada L, Cano VC, Sánchez-Hervás M, Guenther M, Romero Sanz E, Oteo M, Tremblay C, Martín G, Letourneau D, Montagne M, Morcillo Alonso MÁ, Whitfield JR, Lavigne P, Soucek L. Beaulieu ME, et al. Among authors: soucek l. Sci Transl Med. 2019 Mar 20;11(484):eaar5012. doi: 10.1126/scitranslmed.aar5012. Sci Transl Med. 2019. PMID: 30894502 Free PMC article.
Myc and Ras, the Bonnie and Clyde of immune evasion.
Casacuberta-Serra S, Soucek L. Casacuberta-Serra S, et al. Among authors: soucek l. Transl Cancer Res. 2018 Apr;7(Suppl 4):S457-S459. doi: 10.21037/tcr.2018.03.09. Transl Cancer Res. 2018. PMID: 31579305 Free PMC article. No abstract available.
MYC, MYCL, and MYCN as therapeutic targets in lung cancer.
Massó-Vallés D, Beaulieu ME, Soucek L. Massó-Vallés D, et al. Among authors: soucek l. Expert Opin Ther Targets. 2020 Feb;24(2):101-114. doi: 10.1080/14728222.2020.1723548. Epub 2020 Feb 13. Expert Opin Ther Targets. 2020. PMID: 32003251 Review.
An "-omycs" Toolbox to Work with MYC.
Whitfield J, Soucek L. Whitfield J, et al. Among authors: soucek l. Methods Mol Biol. 2021;2318:1-11. doi: 10.1007/978-1-0716-1476-1_1. Methods Mol Biol. 2021. PMID: 34019283
74 results