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Page 1
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. Komatsu M, et al. Among authors: sou ys. Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173742
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K. Komatsu M, et al. Among authors: sou ys. Cell. 2007 Dec 14;131(6):1149-63. doi: 10.1016/j.cell.2007.10.035. Cell. 2007. PMID: 18083104 Free article.
Structural basis for sorting mechanism of p62 in selective autophagy.
Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M. Ichimura Y, et al. Among authors: sou ys. J Biol Chem. 2008 Aug 15;283(33):22847-57. doi: 10.1074/jbc.M802182200. Epub 2008 Jun 4. J Biol Chem. 2008. PMID: 18524774 Free article.
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M. Ichimura Y, et al. Among authors: sou ys. Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5. Mol Cell. 2013. PMID: 24011591 Free article.
LC3B is indispensable for selective autophagy of p62 but not basal autophagy.
Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y. Maruyama Y, et al. Among authors: sou ys. Biochem Biophys Res Commun. 2014 Mar 28;446(1):309-15. doi: 10.1016/j.bbrc.2014.02.093. Epub 2014 Feb 28. Biochem Biophys Res Commun. 2014. PMID: 24582747
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, Komatsu M. Kageyama S, et al. Among authors: sou ys. J Biol Chem. 2014 Sep 5;289(36):24944-55. doi: 10.1074/jbc.M114.580357. Epub 2014 Jul 21. J Biol Chem. 2014. PMID: 25049227 Free PMC article.
NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system.
Sánchez-Martín P, Sou YS, Kageyama S, Koike M, Waguri S, Komatsu M. Sánchez-Martín P, et al. Among authors: sou ys. EMBO Rep. 2020 Mar 4;21(3):e48902. doi: 10.15252/embr.201948902. Epub 2020 Jan 9. EMBO Rep. 2020. PMID: 31916398 Free PMC article.
p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response.
Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M. Kageyama S, et al. Among authors: sou ys. Nat Commun. 2021 Jan 4;12(1):16. doi: 10.1038/s41467-020-20185-1. Nat Commun. 2021. PMID: 33397898 Free PMC article.
28 results