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Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response.
Shih HP, Ding JY, Sotolongo Bellón J, Lo YF, Chung PH, Ting HT, Peng JJ, Wu TY, Lin CH, Lo CC, Lin YN, Yeh CF, Chen JB, Wu TS, Liu YM, Kuo CY, Wang SY, Tu KH, Ng CY, Lei WT, Tsai YH, Chen JH, Chuang YT, Huang JY, Rey FA, Chen HK, Chang TW, Piehler J, Chi CY, Ku CL. Shih HP, et al. Among authors: sotolongo bellon j. J Exp Med. 2022 Sep 5;219(9):e20212126. doi: 10.1084/jem.20212126. Epub 2022 Jul 14. J Exp Med. 2022. PMID: 35833912 Free PMC article.
Structure of the IFNγ receptor complex guides design of biased agonists.
Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Mendoza JL, et al. Among authors: sotolongo bellon j. Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27. Nature. 2019. PMID: 30814731 Free PMC article.
Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.
Gorby C, Sotolongo Bellón J, Wilmes S, Warda W, Pohler E, Fyfe PK, Cozzani A, Ferrand C, Walter MR, Mitra S, Piehler J, Moraga I. Gorby C, et al. Among authors: sotolongo bellon j. Sci Signal. 2020 Sep 15;13(649):eabc0653. doi: 10.1126/scisignal.abc0653. Sci Signal. 2020. PMID: 32934073 Free PMC article.