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Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response.
J Exp Med. 2022 Sep 5;219(9):e20212126. doi: 10.1084/jem.20212126. Epub 2022 Jul 14.
J Exp Med. 2022.
PMID: 35833912
Free PMC article.
Structure of the IFNγ receptor complex guides design of biased agonists.
Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC.
Mendoza JL, et al. Among authors: sotolongo bellon j.
Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27.
Nature. 2019.
PMID: 30814731
Free PMC article.
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Four-color single-molecule imaging with engineered tags resolves the molecular architecture of signaling complexes in the plasma membrane.
Sotolongo Bellón J, Birkholz O, Richter CP, Eull F, Kenneweg H, Wilmes S, Rothbauer U, You C, Walter MR, Kurre R, Piehler J.
Sotolongo Bellón J, et al.
Cell Rep Methods. 2022 Feb 4;2(2):100165. doi: 10.1016/j.crmeth.2022.100165. eCollection 2022 Feb 28.
Cell Rep Methods. 2022.
PMID: 35474965
Free PMC article.
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Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.
Gorby C, Sotolongo Bellón J, Wilmes S, Warda W, Pohler E, Fyfe PK, Cozzani A, Ferrand C, Walter MR, Mitra S, Piehler J, Moraga I.
Gorby C, et al. Among authors: sotolongo bellon j.
Sci Signal. 2020 Sep 15;13(649):eabc0653. doi: 10.1126/scisignal.abc0653.
Sci Signal. 2020.
PMID: 32934073
Free PMC article.
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