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Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia.
Dijk W, Di Filippo M, Kooijman S, van Eenige R, Rimbert A, Caillaud A, Thedrez A, Arnaud L, Pronk A, Garçon D, Sotin T, Lindenbaum P, Ozcariz Garcia E, Pais de Barros JP, Duvillard L, Si-Tayeb K, Amigo N, Le Questel JY, Rensen PCN, Le May C, Moulin P, Cariou B. Dijk W, et al. Among authors: sotin t. Circulation. 2022 Sep 6;146(10):724-739. doi: 10.1161/CIRCULATIONAHA.121.057978. Epub 2022 Jul 28. Circulation. 2022. PMID: 35899625 Free PMC article.
PCSK9 is not secreted from mature differentiated intestinal cells.
Moreau F, Thédrez A, Garçon D, Ayer A, Sotin T, Dijk W, Blanchard C, Chadeuf G, Arnaud L, Croyal M, Van Landeghem L, Touvron M, Prieur X, Roubtsova A, Seidah N, Prat A, Cariou B, Le May C. Moreau F, et al. Among authors: sotin t. J Lipid Res. 2021;62:100096. doi: 10.1016/j.jlr.2021.100096. Epub 2021 Jul 17. J Lipid Res. 2021. PMID: 34280453 Free PMC article.
PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol.
Roubtsova A, Garçon D, Lacoste S, Chamberland A, Marcinkiewicz J, Métivier R, Sotin T, Paquette M, Bernard S, Cariou B, Le May C, Koschinsky ML, Seidah NG, Prat A. Roubtsova A, et al. Among authors: sotin t. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Dec;1867(12):159217. doi: 10.1016/j.bbalip.2022.159217. Epub 2022 Aug 17. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35985474 Free article.
Corrigendum: PCSK9 is not secreted from mature differentiated intestinal cells.
Moreau F, Thédrez A, Garçon D, Ayer A, Sotin T, Dijk W, Blanchard C, Chadeuf G, Arnaud L, Croyal M, Van Landeghem L, Touvron M, Prieur X, Roubtsova A, Seidah N, Prat A, Cariou B, Le May C. Moreau F, et al. Among authors: sotin t. J Lipid Res. 2022 Apr;63(4):100186. doi: 10.1016/j.jlr.2022.100186. Epub 2022 Mar 14. J Lipid Res. 2022. PMID: 35298954 Free PMC article. No abstract available.
PCSK9 inhibition protects mice from food allergy.
Lorant V, Klein M, Garçon D, Sotin T, Frey S, Cheminant MA, Ayer A, Croyal M, Flet L, Rimbert A, Colas L, Cariou B, Bouchaud G, Le May C. Lorant V, et al. Among authors: sotin t. Transl Res. 2024 Mar 11:S1931-5244(24)00048-3. doi: 10.1016/j.trsl.2024.03.001. Online ahead of print. Transl Res. 2024. PMID: 38471633