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Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6.
Sorokin AV, Kanikarla Marie P, Bitner L, Syed M, Woods M, Manyam G, Kwong LN, Johnson B, Morris VK, Jones P, Menter DG, Lee MS, Kopetz S. Sorokin AV, et al. Cancer Res. 2022 Sep 16;82(18):3335-3344. doi: 10.1158/0008-5472.CAN-22-0198. Cancer Res. 2022. PMID: 35913398 Free PMC article.
Modeling of Patient-Derived Xenografts in Colorectal Cancer.
Katsiampoura A, Raghav K, Jiang ZQ, Menter DG, Varkaris A, Morelli MP, Manuel S, Wu J, Sorokin AV, Rizi BS, Bristow C, Tian F, Airhart S, Cheng M, Broom BM, Morris J, Overman MJ, Powis G, Kopetz S. Katsiampoura A, et al. Among authors: sorokin av. Mol Cancer Ther. 2017 Jul;16(7):1435-1442. doi: 10.1158/1535-7163.MCT-16-0721. Epub 2017 May 3. Mol Cancer Ther. 2017. PMID: 28468778 Free PMC article.
Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406).
Kopetz S, Guthrie KA, Morris VK, Lenz HJ, Magliocco AM, Maru D, Yan Y, Lanman R, Manyam G, Hong DS, Sorokin A, Atreya CE, Diaz LA, Allegra C, Raghav KP, Wang SE, Lieu CH, McDonough SL, Philip PA, Hochster HS. Kopetz S, et al. J Clin Oncol. 2021 Feb 1;39(4):285-294. doi: 10.1200/JCO.20.01994. Epub 2020 Dec 23. J Clin Oncol. 2021. PMID: 33356422 Free PMC article. Clinical Trial.
Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression.
Napolitano S, Matrone N, Muddassir AL, Martini G, Sorokin A, De Falco V, Giunta EF, Ciardiello D, Martinelli E, Belli V, Furia M, Kopetz S, Morgillo F, Ciardiello F, Troiani T. Napolitano S, et al. J Exp Clin Cancer Res. 2019 Dec 16;38(1):492. doi: 10.1186/s13046-019-1497-0. J Exp Clin Cancer Res. 2019. PMID: 31842958 Free PMC article.
Phase IB Study of Vemurafenib in Combination with Irinotecan and Cetuximab in Patients with Metastatic Colorectal Cancer with BRAFV600E Mutation.
Hong DS, Morris VK, El Osta B, Sorokin AV, Janku F, Fu S, Overman MJ, Piha-Paul S, Subbiah V, Kee B, Tsimberidou AM, Fogelman D, Bellido J, Shureiqi I, Huang H, Atkins J, Tarcic G, Sommer N, Lanman R, Meric-Bernstam F, Kopetz S. Hong DS, et al. Among authors: sorokin av. Cancer Discov. 2016 Dec;6(12):1352-1365. doi: 10.1158/2159-8290.CD-16-0050. Epub 2016 Oct 11. Cancer Discov. 2016. PMID: 27729313 Free PMC article.
Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.
Loree JM, Wang Y, Syed MA, Sorokin AV, Coker O, Xiu J, Weinberg BA, Vanderwalde AM, Tesfaye A, Raymond VM, Miron B, Tarcic G, Zelichov O, Broaddus RR, Ng PKS, Jeong KJ, Tsang YH, Mills GB, Overman MJ, Grothey A, Marshall JL, Kopetz S. Loree JM, et al. Among authors: sorokin av. Clin Cancer Res. 2021 Aug 15;27(16):4587-4598. doi: 10.1158/1078-0432.CCR-21-0180. Epub 2021 Jun 11. Clin Cancer Res. 2021. PMID: 34117033 Free PMC article.
Autologous humanized mouse models to study combination and single-agent immunotherapy for colorectal cancer patient-derived xenografts.
Kanikarla Marie P, Sorokin AV, Bitner LA, Aden R, Lam M, Manyam G, Woods MN, Anderson A, Capasso A, Fowlkes N, Overman MJ, Menter DG, Kopetz S. Kanikarla Marie P, et al. Among authors: sorokin av. Front Oncol. 2022 Sep 21;12:994333. doi: 10.3389/fonc.2022.994333. eCollection 2022. Front Oncol. 2022. PMID: 36212401 Free PMC article.
The Provocative Roles of Platelets in Liver Disease and Cancer.
Kanikarla Marie P, Fowlkes NW, Afshar-Kharghan V, Martch SL, Sorokin A, Shen JP, Morris VK, Dasari A, You N, Sood AK, Overman MJ, Kopetz S, Menter DG. Kanikarla Marie P, et al. Front Oncol. 2021 Jul 21;11:643815. doi: 10.3389/fonc.2021.643815. eCollection 2021. Front Oncol. 2021. PMID: 34367949 Free PMC article. Review.
200 results