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Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hällberg BM, Löw C. Custódio TF, et al. Among authors: sorgenfrei m. Nat Commun. 2020 Nov 4;11(1):5588. doi: 10.1038/s41467-020-19204-y. Nat Commun. 2020. PMID: 33149112 Free PMC article.
Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance.
Walter JD, Scherer M, Hutter CAJ, Garaeva AA, Zimmermann I, Wyss M, Rheinberger J, Ruedin Y, Earp JC, Egloff P, Sorgenfrei M, Hürlimann LM, Gonda I, Meier G, Remm S, Thavarasah S, van Geest G, Bruggmann R, Zimmer G, Slotboom DJ, Paulino C, Plattet P, Seeger MA. Walter JD, et al. Among authors: sorgenfrei m. EMBO Rep. 2022 Apr 5;23(4):e54199. doi: 10.15252/embr.202154199. Epub 2022 Mar 7. EMBO Rep. 2022. PMID: 35253970 Free PMC article.
Biomolecules capturing live bacteria from clinical samples.
Sorgenfrei M, Hürlimann LM, Remy MM, Keller PM, Seeger MA. Sorgenfrei M, et al. Trends Biochem Sci. 2022 Aug;47(8):673-688. doi: 10.1016/j.tibs.2022.03.018. Epub 2022 Apr 27. Trends Biochem Sci. 2022. PMID: 35487808 Review.
Profiling the interactome of oligonucleotide drugs by proximity biotinylation.
Hanswillemenke A, Hofacker DT, Sorgenfrei M, Fruhner C, Franz-Wachtel M, Schwarzer D, Maček B, Stafforst T. Hanswillemenke A, et al. Among authors: sorgenfrei m. Nat Chem Biol. 2024 May;20(5):555-565. doi: 10.1038/s41589-023-01530-z. Epub 2024 Jan 17. Nat Chem Biol. 2024. PMID: 38233583 Free PMC article.
Creating overview and summary figures.
Critcher M, Gruijs da Silva LA, Dormann D, Campbell ZT, Le TK, Rocchi P, Sorgenfrei M. Critcher M, et al. Among authors: sorgenfrei m. Trends Biochem Sci. 2023 Feb;48(2):97-99. doi: 10.1016/j.tibs.2022.09.009. Trends Biochem Sci. 2023. PMID: 36669467 No abstract available.