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Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.
Hutterer C, Milbradt J, Hamilton S, Zaja M, Leban J, Henry C, Vitt D, Steingruber M, Sonntag E, Zeitträger I, Bahsi H, Stamminger T, Rawlinson W, Strobl S, Marschall M. Hutterer C, et al. Among authors: sonntag e. Antiviral Res. 2017 Jul;143:113-121. doi: 10.1016/j.antiviral.2017.04.003. Epub 2017 Apr 9. Antiviral Res. 2017. PMID: 28400201
The Prolyl Isomerase Pin1 Promotes the Herpesvirus-Induced Phosphorylation-Dependent Disassembly of the Nuclear Lamina Required for Nucleocytoplasmic Egress.
Milbradt J, Hutterer C, Bahsi H, Wagner S, Sonntag E, Horn AH, Kaufer BB, Mori Y, Sticht H, Fossen T, Marschall M. Milbradt J, et al. Among authors: sonntag e. PLoS Pathog. 2016 Aug 24;12(8):e1005825. doi: 10.1371/journal.ppat.1005825. eCollection 2016 Aug. PLoS Pathog. 2016. PMID: 27556400 Free PMC article.
Differential upregulation of host cell protein kinases by the replication of α-, β- and γ-herpesviruses provides a signature of virus-specific signalling.
Marschall M, Strojan H, Kiener R, Wangen C, Sonntag E, Müller R, Zeitträger I, Wagner S, Stamminger T, Milbradt J, Behrends U, Körber N, Bauer T, Schrödel S, Thirion C, Wagner R, Hutterer C. Marschall M, et al. Among authors: sonntag e. J Gen Virol. 2020 Mar;101(3):284-289. doi: 10.1099/jgv.0.001370. J Gen Virol. 2020. PMID: 31958050
Phenotypical Characterization of the Nuclear Egress of Recombinant Cytomegaloviruses Reveals Defective Replication upon ORF-UL50 Deletion but Not pUL50 Phosphosite Mutation.
Häge S, Sonntag E, Svrlanska A, Borst EM, Stilp AC, Horsch D, Müller R, Kropff B, Milbradt J, Stamminger T, Schlötzer-Schrehardt U, Marschall M. Häge S, et al. Among authors: sonntag e. Viruses. 2021 Jan 22;13(2):165. doi: 10.3390/v13020165. Viruses. 2021. PMID: 33499341 Free PMC article.
Patient-Derived Cytomegaloviruses with Different Ganciclovir Sensitivities from UL97 Mutation Retain Their Replication Efficiency and Some Kinase Activity In Vitro.
Wong DD, van Zuylen WJ, Hamilton ST, Steingruber M, Sonntag E, Marschall M, Rawlinson WD. Wong DD, et al. Among authors: sonntag e. Antimicrob Agents Chemother. 2019 Aug 23;63(9):e02425-18. doi: 10.1128/AAC.02425-18. Print 2019 Sep. Antimicrob Agents Chemother. 2019. PMID: 31262766 Free PMC article.
27 results