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Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Montoya S, Bourcier J, Noviski M, Lu H, Thompson MC, Chirino A, Jahn J, Sondhi AK, Gajewski S, Tan YSM, Yung S, Urban A, Wang E, Han C, Mi X, Kim WJ, Sievers Q, Auger P, Bousquet H, Brathaban N, Bravo B, Gessner M, Guiducci C, Iuliano JN, Kane T, Mukerji R, Reddy PJ, Powers J, Sanchez Garcia de Los Rios M, Ye J, Barrientos Risso C, Tsai D, Pardo G, Notti RQ, Pardo A, Affer M, Nawaratne V, Totiger TM, Pena-Velasquez C, Rhodes JM, Zelenetz AD, Alencar A, Roeker LE, Mehta S, Garippa R, Linley A, Soni RK, Skånland SS, Brown RJ, Mato AR, Hansen GM, Abdel-Wahab O, Taylor J. Montoya S, et al. Among authors: soni rk. Science. 2024 Feb 2;383(6682):eadi5798. doi: 10.1126/science.adi5798. Epub 2024 Feb 2. Science. 2024. PMID: 38301010
Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis.
Taylor J, Sendino M, Gorelick AN, Pastore A, Chang MT, Penson AV, Gavrila EI, Stewart C, Melnik EM, Herrejon Chavez F, Bitner L, Yoshimi A, Lee SC, Inoue D, Liu B, Zhang XJ, Mato AR, Dogan A, Kharas MG, Chen Y, Wang D, Soni RK, Hendrickson RC, Prieto G, Rodriguez JA, Taylor BS, Abdel-Wahab O. Taylor J, et al. Among authors: soni rk. Cancer Discov. 2019 Oct;9(10):1452-1467. doi: 10.1158/2159-8290.CD-19-0298. Epub 2019 Jul 8. Cancer Discov. 2019. PMID: 31285298 Free PMC article.
Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia.
Rashkovan M, Albero R, Gianni F, Perez-Duran P, Miller HI, Mackey AL, Paietta EM, Tallman MS, Rowe JM, Litzow MR, Wiernik PH, Luger S, Sulis ML, Soni RK, Ferrando AA. Rashkovan M, et al. Among authors: soni rk. Cancer Discov. 2022 Mar 1;12(3):856-871. doi: 10.1158/2159-8290.CD-21-0551. Cancer Discov. 2022. PMID: 34711640 Free PMC article.
The subacromial bursa modulates tendon healing after rotator cuff injury in rats.
Marshall BP, Ashinsky BG, Ferrer XE, Kunes JA, Innis AC, Luzzi AJ, Forrester LA, Burt KG, Lee AJ, Song L, Lisiewski LE, Soni RK, Hung CT, Levine WN, Kovacevic D, Thomopoulos S. Marshall BP, et al. Among authors: soni rk. Sci Transl Med. 2024 Apr 24;16(744):eadd8273. doi: 10.1126/scitranslmed.add8273. Epub 2024 Apr 24. Sci Transl Med. 2024. PMID: 38657023
Anti-tumor effects of an ID antagonist with no observed acquired resistance.
Wojnarowicz PM, Escolano MG, Huang YH, Desai B, Chin Y, Shah R, Xu S, Yadav S, Yaklichkin S, Ouerfelli O, Soni RK, Philip J, Montrose DC, Healey JH, Rajasekhar VK, Garland WA, Ratiu J, Zhuang Y, Norton L, Rosen N, Hendrickson RC, Zhou XK, Iavarone A, Massague J, Dannenberg AJ, Lasorella A, Benezra R. Wojnarowicz PM, et al. Among authors: soni rk. NPJ Breast Cancer. 2021 May 24;7(1):58. doi: 10.1038/s41523-021-00266-0. NPJ Breast Cancer. 2021. PMID: 34031428 Free PMC article.
KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.
Vlasevska S, Garcia-Ibanez L, Duval R, Holmes AB, Jahan R, Cai B, Kim A, Mo T, Basso K, Soni RK, Bhagat G, Dalla-Favera R, Pasqualucci L. Vlasevska S, et al. Among authors: soni rk. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218330120. doi: 10.1073/pnas.2218330120. Epub 2023 Mar 9. Proc Natl Acad Sci U S A. 2023. PMID: 36893259 Free PMC article.
Pathological remodeling of distal lung matrix in end-stage cystic fibrosis patients.
Pinezich MR, Tamargo MA, Fleischer S, Reimer JA, Hudock MR, Hozain AE, Kaslow SR, Tipograf Y, Soni RK, Gavaudan OP, Guenthart BA, Marboe CC, Bacchetta M, O'Neill JD, Dorrello NV, Vunjak-Novakovic G. Pinezich MR, et al. Among authors: soni rk. J Cyst Fibros. 2022 Nov;21(6):1027-1035. doi: 10.1016/j.jcf.2022.04.016. Epub 2022 May 5. J Cyst Fibros. 2022. PMID: 35525782 Free PMC article.
179 results