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Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice.
Zu T, Guo S, Bardhi O, Ryskamp DA, Li J, Khoramian Tusi S, Engelbrecht A, Klippel K, Chakrabarty P, Nguyen L, Golde TE, Sonenberg N, Ranum LPW. Zu T, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18591-18599. doi: 10.1073/pnas.2005748117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690681 Free PMC article.
Identification of differential translation in genome wide studies.
Larsson O, Sonenberg N, Nadon R. Larsson O, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21487-92. doi: 10.1073/pnas.1006821107. Epub 2010 Nov 29. Proc Natl Acad Sci U S A. 2010. PMID: 21115840 Free PMC article.
eIF2α phosphorylation controls thermal nociception.
Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N. Khoutorsky A, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. doi: 10.1073/pnas.1614047113. Epub 2016 Oct 3. Proc Natl Acad Sci U S A. 2016. PMID: 27698114 Free PMC article.
Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.
Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N. Tahmasebi S, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367. doi: 10.1073/pnas.1615540113. Epub 2016 Oct 24. Proc Natl Acad Sci U S A. 2016. PMID: 27791185 Free PMC article.
Proposing a mechanism of action for ataluren.
Siddiqui N, Sonenberg N. Siddiqui N, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12353-12355. doi: 10.1073/pnas.1615548113. Epub 2016 Oct 19. Proc Natl Acad Sci U S A. 2016. PMID: 27791186 Free PMC article. No abstract available.
Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2.
Wiebe S, Nagpal A, Truong VT, Park J, Skalecka A, He AJ, Gamache K, Khoutorsky A, Gantois I, Sonenberg N. Wiebe S, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18060-18067. doi: 10.1073/pnas.1908126116. Epub 2019 Aug 19. Proc Natl Acad Sci U S A. 2019. PMID: 31427534 Free PMC article.
Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission.
De Gregorio D, Popic J, Enns JP, Inserra A, Skalecka A, Markopoulos A, Posa L, Lopez-Canul M, Qianzi H, Lafferty CK, Britt JP, Comai S, Aguilar-Valles A, Sonenberg N, Gobbi G. De Gregorio D, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2020705118. doi: 10.1073/pnas.2020705118. Proc Natl Acad Sci U S A. 2021. PMID: 33495318 Free PMC article.
679 results