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Page 1
Fragile X syndrome.
Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB Jr, Moine H, Kooy RF, Tassone F, Gantois I, Sonenberg N, Mandel JL, Hagerman PJ. Hagerman RJ, et al. Among authors: sonenberg n. Nat Rev Dis Primers. 2017 Sep 29;3:17065. doi: 10.1038/nrdp.2017.65. Nat Rev Dis Primers. 2017. PMID: 28960184 Review.
Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.
Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Gkogkas CG, et al. Among authors: sonenberg n. Cell Rep. 2014 Dec 11;9(5):1742-1755. doi: 10.1016/j.celrep.2014.10.064. Epub 2014 Nov 26. Cell Rep. 2014. PMID: 25466251 Free PMC article.
Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Gantois I, et al. Among authors: sonenberg n. Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15. Nat Med. 2017. PMID: 28504725 Free article.
Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2.
Wiebe S, Nagpal A, Truong VT, Park J, Skalecka A, He AJ, Gamache K, Khoutorsky A, Gantois I, Sonenberg N. Wiebe S, et al. Among authors: sonenberg n. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18060-18067. doi: 10.1073/pnas.1908126116. Epub 2019 Aug 19. Proc Natl Acad Sci U S A. 2019. PMID: 31427534 Free PMC article.
Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells.
Bell S, McCarty V, Peng H, Jefri M, Hettige N, Antonyan L, Crapper L, O'Leary LA, Zhang X, Zhang Y, Wu H, Sutcliffe D, Kolobova I, Rosenberger TA, Moquin L, Gratton A, Popic J, Gantois I, Stumpf PS, Schuppert AA, Mechawar N, Sonenberg N, Tremblay ML, Jinnah HA, Ernst C. Bell S, et al. Among authors: sonenberg n. Stem Cell Reports. 2021 Jul 13;16(7):1749-1762. doi: 10.1016/j.stemcr.2021.06.003. Epub 2021 Jul 1. Stem Cell Reports. 2021. PMID: 34214487 Free PMC article.
Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2.
Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello AC, Seidah N, Sossin W, Lacaille JC, Ron D, Nader K, Sonenberg N. Costa-Mattioli M, et al. Among authors: sonenberg n. Nature. 2005 Aug 25;436(7054):1166-73. doi: 10.1038/nature03897. Nature. 2005. PMID: 16121183 Free PMC article.
Autism-related deficits via dysregulated eIF4E-dependent translational control.
Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N. Gkogkas CG, et al. Among authors: sonenberg n. Nature. 2013 Jan 17;493(7432):371-7. doi: 10.1038/nature11628. Epub 2012 Nov 21. Nature. 2013. PMID: 23172145 Free PMC article.
Antidepressant actions of ketamine engage cell-specific translation via eIF4E.
Aguilar-Valles A, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Khlaifia A, Skaleka A, Lopez-Canul M, Torres-Berrio A, Bermudez S, Rurak GM, Simard S, Salmaso N, Gobbi G, Lacaille JC, Sonenberg N. Aguilar-Valles A, et al. Among authors: sonenberg n. Nature. 2021 Feb;590(7845):315-319. doi: 10.1038/s41586-020-03047-0. Epub 2020 Dec 16. Nature. 2021. PMID: 33328636
679 results