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Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo.
Schueffl H, Theiner S, Hermann G, Mayr J, Fronik P, Groza D, van Schonhooven S, Galvez L, Sommerfeld NS, Schintlmeister A, Reipert S, Wagner M, Mader RM, Koellensperger G, Keppler BK, Berger W, Kowol CR, Legin A, Heffeter P. Schueffl H, et al. Among authors: sommerfeld ns. Chem Sci. 2021 Aug 26;12(38):12587-12599. doi: 10.1039/d1sc03311e. eCollection 2021 Oct 6. Chem Sci. 2021. PMID: 34703544 Free PMC article.
Nano-scale imaging of dual stable isotope labeled oxaliplatin in human colon cancer cells reveals the nucleolus as a putative node for therapeutic effect.
Legin AA, Schintlmeister A, Sommerfeld NS, Eckhard M, Theiner S, Reipert S, Strohhofer D, Jakupec MA, Galanski MS, Wagner M, Keppler BK. Legin AA, et al. Among authors: sommerfeld ns. Nanoscale Adv. 2020 Nov 26;3(1):249-262. doi: 10.1039/d0na00685h. eCollection 2021 Jan 7. Nanoscale Adv. 2020. PMID: 36131874 Free PMC article.
Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents-A Novel Polymer Formulation for Anticancer Therapy.
Lerchbammer-Kreith Y, Hejl M, Sommerfeld NS, Weng-Jiang X, Odunze U, Mellor RD, Workman DG, Jakupec MA, Schätzlein AG, Uchegbu IF, Galanski MS, Keppler BK. Lerchbammer-Kreith Y, et al. Among authors: sommerfeld ns. Pharmaceuticals (Basel). 2023 Jul 19;16(7):1027. doi: 10.3390/ph16071027. Pharmaceuticals (Basel). 2023. PMID: 37513938 Free PMC article.