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SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia.
Brain. 2023 Apr 19;146(4):1420-1435. doi: 10.1093/brain/awac460.
Brain. 2023.
PMID: 36718090
Free PMC article.
Structural insights into the regulation of human serine palmitoyltransferase complexes.
Wang Y, Niu Y, Zhang Z, Gable K, Gupta SD, Somashekarappa N, Han G, Zhao H, Myasnikov AG, Kalathur RC, Dunn TM, Lee CH.
Wang Y, et al. Among authors: somashekarappa n.
Nat Struct Mol Biol. 2021 Mar;28(3):240-248. doi: 10.1038/s41594-020-00551-9. Epub 2021 Feb 8.
Nat Struct Mol Biol. 2021.
PMID: 33558761
Free PMC article.
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Erratum: Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase.
Harrison PJ, Gable K, Somashekarappa N, Kelly V, Clarke DJ, Naismith JH, Dunn TM, Campopiano DJ.
Harrison PJ, et al. Among authors: somashekarappa n.
J Lipid Res. 2019 Aug;60(8):1489. doi: 10.1194/jlr.ERR119000228.
J Lipid Res. 2019.
PMID: 31371643
Free PMC article.
No abstract available.
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Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase.
Harrison PJ, Gable K, Somashekarappa N, Kelly V, Clarke DJ, Naismith JH, Dunn TM, Campopiano DJ.
Harrison PJ, et al. Among authors: somashekarappa n.
J Lipid Res. 2019 May;60(5):953-962. doi: 10.1194/jlr.M089367. Epub 2019 Feb 21.
J Lipid Res. 2019.
PMID: 30792183
Free PMC article.
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The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization.
Han G, Gupta SD, Gable K, Bacikova D, Sengupta N, Somashekarappa N, Proia RL, Harmon JM, Dunn TM.
Han G, et al. Among authors: somashekarappa n.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):245-259. doi: 10.1016/j.bbalip.2018.11.007. Epub 2018 Dec 6.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019.
PMID: 30529276
Free PMC article.
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Regulation of sphingolipid biosynthesis by the morphogenesis checkpoint kinase Swe1.
Chauhan N, Han G, Somashekarappa N, Gable K, Dunn T, Kohlwein SD.
Chauhan N, et al. Among authors: somashekarappa n.
J Biol Chem. 2017 Jun 2;292(22):9431. doi: 10.1074/jbc.A115.693200.
J Biol Chem. 2017.
PMID: 28576886
Free PMC article.
No abstract available.
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Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1.
Chauhan N, Han G, Somashekarappa N, Gable K, Dunn T, Kohlwein SD.
Chauhan N, et al. Among authors: somashekarappa n.
J Biol Chem. 2016 Jan 29;291(5):2524-34. doi: 10.1074/jbc.M115.693200. Epub 2015 Dec 3.
J Biol Chem. 2016.
PMID: 26634277
Free PMC article.
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Topological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferase.
Harmon JM, Bacikova D, Gable K, Gupta SD, Han G, Sengupta N, Somashekarappa N, Dunn TM.
Harmon JM, et al. Among authors: somashekarappa n.
J Biol Chem. 2013 Apr 5;288(14):10144-10153. doi: 10.1074/jbc.M113.451526. Epub 2013 Feb 20.
J Biol Chem. 2013.
PMID: 23426370
Free PMC article.
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