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p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis.
Solé L, Lobo-Jarne T, Álvarez-Villanueva D, Alonso-Marañón J, Guillén Y, Guix M, Sangrador I, Rozalén C, Vert A, Barbachano A, Lop J, Salido M, Bellosillo B, García-Romero R, Garrido M, González J, Martínez-Iniesta M, López-Arribillaga E, Salazar R, Montagut C, Torres F, Iglesias M, Celià-Terrassa T, Muñoz A, Villanueva A, Bigas A, Espinosa L. Solé L, et al. Nat Commun. 2022 May 23;13(1):2866. doi: 10.1038/s41467-022-30382-9. Nat Commun. 2022. PMID: 35606354 Free PMC article.
IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Colomer C, Margalef P, Villanueva A, Vert A, Pecharroman I, Solé L, González-Farré M, Alonso J, Montagut C, Martinez-Iniesta M, Bertran J, Borràs E, Iglesias M, Sabidó E, Bigas A, Boulton SJ, Espinosa L. Colomer C, et al. Among authors: sole l. Mol Cell. 2019 Aug 22;75(4):669-682.e5. doi: 10.1016/j.molcel.2019.05.036. Epub 2019 Jul 10. Mol Cell. 2019. PMID: 31302002 Free PMC article.
Combination of chemotherapy with BRAF inhibitors results in effective eradication of malignant melanoma by preventing ATM-dependent DNA repair.
Alonso-Marañón J, Villanueva A, Piulats JM, Martínez-Iniesta M, Solé L, Martín-Liberal J, Segura S, Pujol RM, Iglesias M, Bigas A, Gallardo F, Espinosa L. Alonso-Marañón J, et al. Among authors: sole l. Oncogene. 2021 Aug;40(31):5042-5048. doi: 10.1038/s41388-021-01879-2. Epub 2021 Jun 17. Oncogene. 2021. PMID: 34140639
Sézary syndrome patient-derived models allow drug selection for personalized therapy.
Gallardo F, Andrades E, Iglesias A, González J, Solé L, Guillén Y, Blanco G, Colomo L, Gimeno E, Conde D, Rodriguez E, Bielsa-Marso I, Iglesias M, Bellosillo B, Pujol RM, Regueiro JR, Bigas A, Espinosa L. Gallardo F, et al. Among authors: sole l. Blood Adv. 2022 Jun 14;6(11):3410-3421. doi: 10.1182/bloodadvances.2021006860. Blood Adv. 2022. PMID: 35413113 Free PMC article.
Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas.
Bredel M, Espinosa L, Kim H, Scholtens DM, McElroy JP, Rajbhandari R, Meng W, Kollmeyer TM, Malta TM, Quezada MA, Harsh GR, Lobo-Jarne T, Solé L, Merati A, Nagaraja S, Nair S, White JJ, Thudi NK, Fleming JL, Webb A, Natsume A, Ogawa S, Weber RG, Bertran J, Haque SJ, Hentschel B, Miller CR, Furnari FB, Chan TA, Grosu AL, Weller M, Barnholtz-Sloan JS, Monje M, Noushmehr H, Jenkins RB, Rogers CL, MacDonald DR, Pugh SL, Chakravarti A. Bredel M, et al. Among authors: sole l. Cell Rep Med. 2023 Jun 20;4(6):101082. doi: 10.1016/j.xcrm.2023.101082. Cell Rep Med. 2023. PMID: 37343523 Free PMC article.
IκB kinase-α coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy.
Pecharromán I, Solé L, Álvarez-Villanueva D, Lobo-Jarne T, Alonso-Marañón J, Bertran J, Guillén Y, Montoto Á, Martínez-Iniesta M, García-Hernández V, Giménez G, Salazar R, Santos C, Garrido M, Borràs E, Sabidó E, Bonfill-Teixidor E, Iurlaro R, Seoane J, Villanueva A, Iglesias M, Bigas A, Espinosa L. Pecharromán I, et al. Among authors: sole l. EMBO J. 2023 Nov 2;42(21):e114719. doi: 10.15252/embj.2023114719. Epub 2023 Sep 22. EMBO J. 2023. PMID: 37737566 Free article.
Loss of the epithelial marker CDX1 predicts poor prognosis in early-stage CRC patients.
Solé L, Lobo-Jarne T, Cabré-Romans JJ, González A, Fernández L, Marruecos L, Guix M, Cuatrecasas M, López S, Bellosillo B, Torres F, Iglesias M, Bigas A, Espinosa L. Solé L, et al. Biochim Biophys Acta Mol Cell Res. 2024 Mar;1871(3):119658. doi: 10.1016/j.bbamcr.2024.119658. Epub 2024 Jan 10. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 38216091 Free article.
79 results