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Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor.
Aging Cell. 2024 Apr;23(4):e14083. doi: 10.1111/acel.14083. Epub 2024 Jan 9.
Aging Cell. 2024.
PMID: 38196311
Free PMC article.
Ageing-associated changes in transcriptional elongation influence longevity.
Debès C, Papadakis A, Grönke S, Karalay Ö, Tain LS, Mizi A, Nakamura S, Hahn O, Weigelt C, Josipovic N, Zirkel A, Brusius I, Sofiadis K, Lamprousi M, Lu YX, Huang W, Esmaillie R, Kubacki T, Späth MR, Schermer B, Benzing T, Müller RU, Antebi A, Partridge L, Papantonis A, Beyer A.
Debès C, et al. Among authors: sofiadis k.
Nature. 2023 Apr;616(7958):814-821. doi: 10.1038/s41586-023-05922-y. Epub 2023 Apr 12.
Nature. 2023.
PMID: 37046086
Free PMC article.
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Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes.
Rinzema NJ, Sofiadis K, Tjalsma SJD, Verstegen MJAM, Oz Y, Valdes-Quezada C, Felder AK, Filipovska T, van der Elst S, de Andrade Dos Ramos Z, Han R, Krijger PHL, de Laat W.
Rinzema NJ, et al. Among authors: sofiadis k.
Nat Struct Mol Biol. 2022 Jun;29(6):563-574. doi: 10.1038/s41594-022-00787-7. Epub 2022 Jun 16.
Nat Struct Mol Biol. 2022.
PMID: 35710842
Free PMC article.
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.
Zampetidis CP, Galanos P, Angelopoulou A, Zhu Y, Polyzou A, Karamitros T, Kotsinas A, Lagopati N, Mourkioti I, Mirzazadeh R, Polyzos A, Garnerone S, Mizi A, Gusmao EG, Sofiadis K, Gál Z, Larsen DH, Pefani DE, Demaria M, Tsirigos A, Crosetto N, Maya-Mendoza A, Papaspyropoulos A, Evangelou K, Bartek J, Papantonis A, Gorgoulis VG.
Zampetidis CP, et al. Among authors: sofiadis k.
Mol Cell. 2021 Dec 2;81(23):4907-4923.e8. doi: 10.1016/j.molcel.2021.10.017. Epub 2021 Nov 17.
Mol Cell. 2021.
PMID: 34793711
Free article.
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HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence.
Sofiadis K, Josipovic N, Nikolic M, Kargapolova Y, Übelmesser N, Varamogianni-Mamatsi V, Zirkel A, Papadionysiou I, Loughran G, Keane J, Michel A, Gusmao EG, Becker C, Altmüller J, Georgomanolis T, Mizi A, Papantonis A.
Sofiadis K, et al.
Mol Syst Biol. 2021 Jun;17(6):e9760. doi: 10.15252/msb.20209760.
Mol Syst Biol. 2021.
PMID: 34166567
Free PMC article.
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Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.
Kargapolova Y, Rehimi R, Kayserili H, Brühl J, Sofiadis K, Zirkel A, Palikyras S, Mizi A, Li Y, Yigit G, Hoischen A, Frank S, Russ N, Trautwein J, van Bon B, Gilissen C, Laugsch M, Gusmao EG, Josipovic N, Altmüller J, Nürnberg P, Längst G, Kaiser FJ, Watrin E, Brunner H, Rada-Iglesias A, Kurian L, Wollnik B, Bouazoune K, Papantonis A.
Kargapolova Y, et al. Among authors: sofiadis k.
Nat Commun. 2021 May 21;12(1):3014. doi: 10.1038/s41467-021-23327-1.
Nat Commun. 2021.
PMID: 34021162
Free PMC article.
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HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types.
Zirkel A, Nikolic M, Sofiadis K, Mallm JP, Brackley CA, Gothe H, Drechsel O, Becker C, Altmüller J, Josipovic N, Georgomanolis T, Brant L, Franzen J, Koker M, Gusmao EG, Costa IG, Ullrich RT, Wagner W, Roukos V, Nürnberg P, Marenduzzo D, Rippe K, Papantonis A.
Zirkel A, et al. Among authors: sofiadis k.
Mol Cell. 2018 May 17;70(4):730-744.e6. doi: 10.1016/j.molcel.2018.03.030. Epub 2018 Apr 26.
Mol Cell. 2018.
PMID: 29706538
Free article.
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Cutting a Long Intron Short: Recursive Splicing and Its Implications.
Georgomanolis T, Sofiadis K, Papantonis A.
Georgomanolis T, et al. Among authors: sofiadis k.
Front Physiol. 2016 Nov 29;7:598. doi: 10.3389/fphys.2016.00598. eCollection 2016.
Front Physiol. 2016.
PMID: 27965595
Free PMC article.
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