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In vitro transforming potential, intracellular signaling properties, and sensitivity to a kinase inhibitor (sorafenib) of RET proto-oncogene variants Glu511Lys, Ser649Leu, and Arg886Trp.
Prazeres H, Couto JP, Rodrigues F, Vinagre J, Torres J, Trovisco V, Martins TC, Sobrinho-Simões M, Soares P. Prazeres H, et al. Endocr Relat Cancer. 2011 Jul 1;18(4):401-12. doi: 10.1530/ERC-10-0258. Print 2011 Aug. Endocr Relat Cancer. 2011. PMID: 21551259 Clinical Trial.
mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma.
Faustino A, Couto JP, Pópulo H, Rocha AS, Pardal F, Cameselle-Teijeiro JM, Lopes JM, Sobrinho-Simões M, Soares P. Faustino A, et al. J Clin Endocrinol Metab. 2012 Jul;97(7):E1139-49. doi: 10.1210/jc.2011-2748. Epub 2012 May 1. J Clin Endocrinol Metab. 2012. PMID: 22549934 Free article.
STAT3 negatively regulates thyroid tumorigenesis.
Couto JP, Daly L, Almeida A, Knauf JA, Fagin JA, Sobrinho-Simões M, Lima J, Máximo V, Soares P, Lyden D, Bromberg JF. Couto JP, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2361-70. doi: 10.1073/pnas.1201232109. Epub 2012 Aug 13. Proc Natl Acad Sci U S A. 2012. PMID: 22891351 Free PMC article.
Mitochondria and cancer.
Máximo V, Lima J, Soares P, Sobrinho-Simões M. Máximo V, et al. Virchows Arch. 2009 May;454(5):481-95. doi: 10.1007/s00428-009-0766-2. Epub 2009 Apr 3. Virchows Arch. 2009. PMID: 19343360 Review.
411 results