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Page 1
A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes.
Glunk V, Laber S, Sinnott-Armstrong N, Sobreira DR, Strobel SM, Batista TM, Kubitz P, Moud BN, Ebert H, Huang Y, Brandl B, Garbo G, Honecker J, Stirling DR, Abdennur N, Calabuig-Navarro V, Skurk T, Ocvirk S, Stemmer K, Cimini BA, Carpenter AE, Dankel SN, Lindgren CM, Hauner H, Nobrega MA, Claussnitzer M. Glunk V, et al. Among authors: sobreira dr. Nat Metab. 2023 May;5(5):861-879. doi: 10.1038/s42255-023-00807-w. Epub 2023 May 30. Nat Metab. 2023. PMID: 37253881
Obesity-associated variants within FTO form long-range functional connections with IRX3.
Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA. Smemo S, et al. Among authors: sobreira dr. Nature. 2014 Mar 20;507(7492):371-5. doi: 10.1038/nature13138. Epub 2014 Mar 12. Nature. 2014. PMID: 24646999 Free PMC article.
DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C. Nicodemus-Johnson J, et al. Among authors: sobreira dr. JCI Insight. 2016 Dec 8;1(20):e90151. doi: 10.1172/jci.insight.90151. JCI Insight. 2016. PMID: 27942592 Free PMC article.
Regulatory Landscapes of Nppa and Nppb.
Sobreira DR, Nóbrega MA. Sobreira DR, et al. Circ Res. 2021 Jan 8;128(1):130-132. doi: 10.1161/CIRCRESAHA.120.318495. Epub 2021 Jan 7. Circ Res. 2021. PMID: 33411631 Free PMC article. No abstract available.
Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega MA. Sobreira DR, et al. Science. 2021 Jun 4;372(6546):1085-1091. doi: 10.1126/science.abf1008. Science. 2021. PMID: 34083488 Free PMC article.
Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region.
Aneas I, Decker DC, Howard CL, Sobreira DR, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Tena J, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Gomez-Skarmeta JL, Schoetler N, Ober C, Sperling AI, Nóbrega MA. Aneas I, et al. Among authors: sobreira dr. Nat Commun. 2021 Oct 21;12(1):6115. doi: 10.1038/s41467-021-26347-z. Nat Commun. 2021. PMID: 34675193 Free PMC article.
Genetics of sexually dimorphic adipose distribution in humans.
Hansen GT, Sobreira DR, Weber ZT, Thornburg AG, Aneas I, Zhang L, Sakabe NJ, Joslin AC, Haddad GA, Strobel SM, Laber S, Sultana F, Sahebdel F, Khan K, Li YI, Claussnitzer M, Ye L, Battaglino RA, Nóbrega MA. Hansen GT, et al. Among authors: sobreira dr. Nat Genet. 2023 Mar;55(3):461-470. doi: 10.1038/s41588-023-01306-0. Epub 2023 Feb 16. Nat Genet. 2023. PMID: 36797366 Free PMC article.
Dietary macronutrient composition impacts gene regulation in adipose tissue.
Farris KM, Senior AM, Sobreira DR, Mitchell RM, Weber ZT, Ingerslev LR, Barrès R, Simpson SJ, Crean AJ, Nobrega MA. Farris KM, et al. Among authors: sobreira dr. Commun Biol. 2024 Feb 16;7(1):194. doi: 10.1038/s42003-024-05876-5. Commun Biol. 2024. PMID: 38365885 Free PMC article.
22 results