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The Flavonoid Agathisflavone Directs Brain Microglia/Macrophages to a Neuroprotective Anti-Inflammatory and Antioxidant State via Regulation of NLRP3 Inflammasome.
Dos Santos BL, Dos Santos CC, Soares JRP, da Silva KC, de Oliveira JVR, Pereira GS, de Araújo FM, Costa MFD, David JM, da Silva VDA, Butt AM, Costa SL. Dos Santos BL, et al. Among authors: soares jrp. Pharmaceutics. 2023 May 5;15(5):1410. doi: 10.3390/pharmaceutics15051410. Pharmaceutics. 2023. PMID: 37242652 Free PMC article.
Neuroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastoma.
do Nascimento RP, Dos Santos BL, Amparo JAO, Soares JRP, da Silva KC, Santana MR, Almeida ÁMAN, da Silva VDA, Costa MFD, Ulrich H, Moura-Neto V, Lopes GPF, Costa SL. do Nascimento RP, et al. Among authors: soares jrp. Pharmaceutics. 2022 Jan 4;14(1):116. doi: 10.3390/pharmaceutics14010116. Pharmaceutics. 2022. PMID: 35057010 Free PMC article. Review.
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: soares jrp. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805