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LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D'Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D. Rudalska R, et al. Among authors: snaebjornsson mt. Nat Cancer. 2021 Feb;2(2):201-217. doi: 10.1038/s43018-020-00168-3. Epub 2021 Feb 15. Nat Cancer. 2021. PMID: 35122079
Tumours use a metabolic twist to make lipids.
Snaebjornsson MT, Schulze A. Snaebjornsson MT, et al. Nature. 2019 Feb;566(7744):333-334. doi: 10.1038/d41586-019-00352-1. Nature. 2019. PMID: 30783267 No abstract available.
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Müller A, Spahn M, Seitz AK, Frank T, Marouf H, Büchel G, Eckstein M, Kübler H, Eilers M, Saar M, Junker K, Röhrig F, Kneitz B, Rosenfeldt MT, Schulze A. Kalogirou C, et al. Among authors: snaebjornsson mt. Nat Commun. 2021 Aug 20;12(1):5066. doi: 10.1038/s41467-021-25325-9. Nat Commun. 2021. PMID: 34417456 Free PMC article.
Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma.
Ruiz-Pérez MV, Sainero-Alcolado L, Oliynyk G, Matuschek I, Balboni N, Ubhayasekera SJKA, Snaebjornsson MT, Makowski K, Aaltonen K, Bexell D, Serra D, Nilsson R, Bergquist J, Schulze A, Arsenian-Henriksson M. Ruiz-Pérez MV, et al. Among authors: snaebjornsson mt. iScience. 2021 Feb 1;24(2):102128. doi: 10.1016/j.isci.2021.102128. eCollection 2021 Feb 19. iScience. 2021. PMID: 33659885 Free PMC article.
Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma.
Sainero-Alcolado L, Garde-Lapido E, Snaebjörnsson MT, Schoch S, Stevens I, Ruiz-Pérez MV, Dyrager C, Pelechano V, Axelson H, Schulze A, Arsenian-Henriksson M. Sainero-Alcolado L, et al. Among authors: snaebjornsson mt. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2310479121. doi: 10.1073/pnas.2310479121. Epub 2024 Feb 9. Proc Natl Acad Sci U S A. 2024. PMID: 38335255 Free PMC article.
13C-SpaceM: Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer.
Buglakova E, Ekelöf M, Schwaiger-Haber M, Schlicker L, Molenaar MR, Mohammed S, Stuart L, Eisenbarth A, Hilsenstein V, Patti GJ, Schulze A, Snaebjornsson MT, Alexandrov T. Buglakova E, et al. Among authors: snaebjornsson mt. bioRxiv [Preprint]. 2024 Feb 28:2023.08.18.553810. doi: 10.1101/2023.08.18.553810. bioRxiv. 2024. PMID: 38464218 Free PMC article. Preprint.
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