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Page 1
Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression.
Marcinkowska M, Mordyl B, Fajkis-Zajaczkowska N, Siwek A, Karcz T, Gawalska A, Bucki A, Żmudzki P, Partyka A, Jastrzębska-Więsek M, Pomierny B, Walczak M, Smolik M, Pytka K, Mika K, Kotańska M, Kolaczkowski M. Marcinkowska M, et al. Among authors: smolik m. Eur J Med Chem. 2023 Feb 5;247:115071. doi: 10.1016/j.ejmech.2022.115071. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36603509
Study on the effect of EMD386088, a 5-HT6 receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.
Jastrzębska-Więsek M, Siwek A, Partyka A, Kołaczkowski M, Walczak M, Smolik M, Latacz G, Kieć-Kononowicz K, Wesołowska A. Jastrzębska-Więsek M, et al. Among authors: smolik m. Naunyn Schmiedebergs Arch Pharmacol. 2018 Jan;391(1):37-49. doi: 10.1007/s00210-017-1431-y. Epub 2017 Oct 27. Naunyn Schmiedebergs Arch Pharmacol. 2018. PMID: 29079874 Free PMC article.
The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
Jastrzębska-Więsek M, Kotańska M, Grzeszczak A, Jaromin A, Walczak M, Partyka A, Gdula-Argasińska J, Smolik M, Zagórska A. Jastrzębska-Więsek M, et al. Among authors: smolik m. Int J Mol Sci. 2022 Sep 28;23(19):11452. doi: 10.3390/ijms231911452. Int J Mol Sci. 2022. PMID: 36232749 Free PMC article.
HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.
Pytka K, Głuch-Lutwin M, Żmudzka E, Sałaciak K, Siwek A, Niemczyk K, Walczak M, Smolik M, Olczyk A, Gałuszka A, Śmieja J, Filipek B, Sapa J, Kołaczkowski M, Pańczyk K, Waszkielewicz A, Marona H. Pytka K, et al. Among authors: smolik m. Front Pharmacol. 2018 Oct 16;9:1146. doi: 10.3389/fphar.2018.01146. eCollection 2018. Front Pharmacol. 2018. PMID: 30410441 Free PMC article.
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies.
Panek D, Pasieka A, Latacz G, Zaręba P, Szczęch M, Godyń J, Chantegreil F, Nachon F, Brazzolotto X, Skrzypczak-Wiercioch A, Walczak M, Smolik M, Sałat K, Höfner G, Wanner K, Więckowska A, Malawska B. Panek D, et al. Among authors: smolik m. Eur J Med Chem. 2023 Mar 5;249:115135. doi: 10.1016/j.ejmech.2023.115135. Epub 2023 Jan 18. Eur J Med Chem. 2023. PMID: 36696766
Promising anticonvulsant and/or analgesic compounds among 5-chloro-2- or 5-chloro-4-methyl derivatives of xanthone coupled to aminoalkanol moieties-Design, synthesis and pharmacological evaluation.
Mazur G, Pańczyk-Straszak K, Rapacz A, Kiszela J, Smolik M, Gawlik M, Walczak M, Czekajewska J, Poloczek C, Karczewska E, Żesławska E, Nitek W, Niedbał A, Leśniak J, Ciapala K, Pawlik K, Mika J, Waszkielewicz AM. Mazur G, et al. Among authors: smolik m. Chem Biol Drug Des. 2023 Feb;101(2):278-325. doi: 10.1111/cbdd.14102. Epub 2022 Dec 16. Chem Biol Drug Des. 2023. PMID: 35713377
Quantitative measurement of selected protein biomarkers of endothelial dysfunction in plasma by micro-liquid chromatography-tandem mass spectrometry based on stable isotope dilution method.
Suraj J, Kurpińska A, Sternak M, Smolik M, Niedzielska-Andres E, Zakrzewska A, Sacha T, Kania A, Chlopicki S, Walczak M. Suraj J, et al. Among authors: smolik m. Talanta. 2019 Mar 1;194:1005-1016. doi: 10.1016/j.talanta.2018.10.067. Epub 2018 Oct 23. Talanta. 2019. PMID: 30609507
Development, validation and application of a micro-liquid chromatography-tandem mass spectrometry based method for simultaneous quantification of selected protein biomarkers of endothelial dysfunction in murine plasma.
Suraj J, Kurpińska A, Olkowicz M, Niedzielska-Andres E, Smolik M, Zakrzewska A, Jasztal A, Sitek B, Chlopicki S, Walczak M. Suraj J, et al. Among authors: smolik m. J Pharm Biomed Anal. 2018 Feb 5;149:465-474. doi: 10.1016/j.jpba.2017.11.023. Epub 2017 Nov 10. J Pharm Biomed Anal. 2018. PMID: 29172146
Comparison of anti-cancer effects of novel protein disulphide isomerase (PDI) inhibitors in breast cancer cells characterized by high and low PDIA17 expression.
Kurpińska A, Suraj-Prażmowska J, Stojak M, Jarosz J, Mateuszuk Ł, Niedzielska-Andres E, Smolik M, Wietrzyk J, Kalvins I, Walczak M, Chłopicki S. Kurpińska A, et al. Among authors: smolik m. Cancer Cell Int. 2022 Jun 20;22(1):218. doi: 10.1186/s12935-022-02631-w. Cancer Cell Int. 2022. PMID: 35725466 Free PMC article.
30 results