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TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C.
Hoste L, Roels L, Naesens L, Bosteels V, Vanhee S, Dupont S, Bosteels C, Browaeys R, Vandamme N, Verstaen K, Roels J, Van Damme KFA, Maes B, De Leeuw E, Declercq J, Aegerter H, Seys L, Smole U, De Prijck S, Vanheerswynghels M, Claes K, Debacker V, Van Isterdael G, Backers L, Claes KBM, Bastard P, Jouanguy E, Zhang SY, Mets G, Dehoorne J, Vandekerckhove K, Schelstraete P, Willems J; MIS-C Clinicians; Stordeur P, Janssens S, Beyaert R, Saeys Y, Casanova JL, Lambrecht BN, Haerynck F, Tavernier SJ. Hoste L, et al. Among authors: smole u. J Exp Med. 2022 Feb 7;219(2):e20211381. doi: 10.1084/jem.20211381. Epub 2021 Dec 16. J Exp Med. 2022. PMID: 34914824 Free PMC article.
The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice.
Maes B, Smole U, Vanderkerken M, Deswarte K, Van Moorleghem J, Vergote K, Vanheerswynghels M, De Wolf C, De Prijck S, Debeuf N, Pavie B, Toussaint W, Janssens S, Savvides S, Lambrecht BN, Hammad H. Maes B, et al. Among authors: smole u. J Allergy Clin Immunol. 2022 Apr;149(4):1413-1427.e2. doi: 10.1016/j.jaci.2021.08.020. Epub 2021 Sep 8. J Allergy Clin Immunol. 2022. PMID: 34506849
Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial.
Declercq J, Van Damme KFA, De Leeuw E, Maes B, Bosteels C, Tavernier SJ, De Buyser S, Colman R, Hites M, Verschelden G, Fivez T, Moerman F, Demedts IK, Dauby N, De Schryver N, Govaerts E, Vandecasteele SJ, Van Laethem J, Anguille S, van der Hilst J, Misset B, Slabbynck H, Wittebole X, Liénart F, Legrand C, Buyse M, Stevens D, Bauters F, Seys LJM, Aegerter H, Smole U, Bosteels V, Hoste L, Naesens L, Haerynck F, Vandekerckhove L, Depuydt P, van Braeckel E, Rottey S, Peene I, Van Der Straeten C, Hulstaert F, Lambrecht BN. Declercq J, et al. Among authors: smole u. Lancet Respir Med. 2021 Dec;9(12):1427-1438. doi: 10.1016/S2213-2600(21)00377-5. Epub 2021 Oct 29. Lancet Respir Med. 2021. PMID: 34756178 Free PMC article. Clinical Trial.
The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4+ T cells resembling iTreg.
Tauber PA, Kratzer B, Schatzlmaier P, Smole U, Köhler C, Rausch L, Kranich J, Trapin D, Neunkirchner A, Zabel M, Jutz S, Steinberger P, Gadermaier G, Brocker T, Stockinger H, Derdak S, Pickl WF. Tauber PA, et al. Among authors: smole u. Front Immunol. 2023 Apr 6;14:1094694. doi: 10.3389/fimmu.2023.1094694. eCollection 2023. Front Immunol. 2023. PMID: 37090735 Free PMC article.
Art v 1 IgE epitopes of patients and humanized mice are conformational.
Zabel M, Weber M, Kratzer B, Köhler C, Jahn-Schmid B, Gadermaier G, Gattinger P, Bidovec-Stojkovič U, Korošec P, Smole U, Wurzinger G, Chen KW, Panaitescu CB, Klimek L, Pablos I, Niespodziana K, Neunkirchner A, Keller W, Valenta R, Pickl WF. Zabel M, et al. Among authors: smole u. J Allergy Clin Immunol. 2022 Oct;150(4):920-930. doi: 10.1016/j.jaci.2022.04.031. Epub 2022 Jun 21. J Allergy Clin Immunol. 2022. PMID: 35738928 Free article.
26 results