Smith N - Search Results

1

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.

Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL. Rottner AK, et al. Among authors: smith n. Nat Genet. 2023 Jan;55(1):54-65. doi: 10.1038/s41588-022-01261-2. Epub 2022 Dec 21. Nat Genet. 2023. PMID: 36543916 Free PMC article.

2

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore.

Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AM, Rajotte RV, MacDonald PE. Lyon J, et al. Among authors: smith n. Endocrinology. 2016 Feb;157(2):560-9. doi: 10.1210/en.2015-1562. Epub 2015 Dec 11. Endocrinology. 2016. PMID: 26653569

3

Interleukin-1 signaling contributes to acute islet compensation.

Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE. Hajmrle C, et al. Among authors: smith n. JCI Insight. 2016 Apr 7;1(4):e86055. doi: 10.1172/jci.insight.86055. JCI Insight. 2016. PMID: 27699257 Free PMC article.

4

Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats.

Hamza SM, Sung MM, Gao F, Soltys CM, Smith NP, MacDonald PE, Light PE, Dyck JR. Hamza SM, et al. Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):313-322. doi: 10.1016/j.bbagen.2016.11.029. Epub 2016 Nov 19. Biochim Biophys Acta Gen Subj. 2017. PMID: 27871838

5

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.

Ferdaoussi M, Fu J, Dai X, Manning Fox JE, Suzuki K, Smith N, Plummer G, MacDonald PE. Ferdaoussi M, et al. Among authors: smith n. Sci Rep. 2017 Mar 21;7(1):248. doi: 10.1038/s41598-017-00344-z. Sci Rep. 2017. PMID: 28325894 Free PMC article.

6

A role for PKD1 in insulin secretion downstream of P2Y₁ receptor activation in mouse and human islets.

Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE. Khan S, et al. Among authors: smith n. Physiol Rep. 2019 Oct;7(19):e14250. doi: 10.14814/phy2.14250. Physiol Rep. 2019. PMID: 31591827 Free PMC article.

7

Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion.

Ferdaoussi M, Smith N, Lin H, Bautista A, Spigelman AF, Lyon J, Dai X, Manning Fox JE, MacDonald PE. Ferdaoussi M, et al. Among authors: smith n. Physiol Rep. 2020 Apr;8(8):e14420. doi: 10.14814/phy2.14420. Physiol Rep. 2020. PMID: 32339440 Free PMC article.

8

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice.

Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Alghamdi TA, Lewandowski SL, Jin Y, Bautista A, Wang YW, Manning Fox JE, Merrins MJ, Buteau J, MacDonald PE. Lin H, et al. Among authors: smith n. Diabetes. 2021 Nov;70(11):2626-2638. doi: 10.2337/db20-1235. Epub 2021 Aug 30. Diabetes. 2021. PMID: 34462260 Free PMC article.

9

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.

Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. Dai XQ, et al. Among authors: smith n. Cell Metab. 2022 Feb 1;34(2):256-268.e5. doi: 10.1016/j.cmet.2021.12.021. Cell Metab. 2022. PMID: 35108513 Free PMC article.

10

Impacts of the COVID-19 pandemic on a human research islet program.

Dafoe TJ, Dos Santos T, Spigelman AF, Lyon J, Smith N, Bautista A, MacDonald PE, Manning Fox JE. Dafoe TJ, et al. Among authors: smith n. Islets. 2022 Dec 31;14(1):101-113. doi: 10.1080/19382014.2022.2047571. Islets. 2022. PMID: 35285768 Free PMC article.

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