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J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine.
Kuo A, Imam MZ, Li R, Lin L, Raboczyj A, Bohmer AE, Nicholson JR, Corradini L, Smith MT. Kuo A, et al. Among authors: smith mt. Front Pharmacol. 2024 Jan 22;15:1346801. doi: 10.3389/fphar.2024.1346801. eCollection 2024. Front Pharmacol. 2024. PMID: 38318132 Free PMC article.
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