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Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA, McArthur GA, Sheppard KE. AbuHammad S, et al. Among authors: smith lk. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17990-18000. doi: 10.1073/pnas.1901323116. Epub 2019 Aug 22. Proc Natl Acad Sci U S A. 2019. PMID: 31439820 Free PMC article.
Obesity and the Impact on Cutaneous Melanoma: Friend or Foe?
Smith LK, Arabi S, Lelliott EJ, McArthur GA, Sheppard KE. Smith LK, et al. Cancers (Basel). 2020 Jun 15;12(6):1583. doi: 10.3390/cancers12061583. Cancers (Basel). 2020. PMID: 32549336 Free PMC article. Review.
Melanoma brain metastases that progress on BRAF-MEK inhibitors demonstrate resistance to ipilimumab-nivolumab that is associated with the Innate PD-1 Resistance Signature (IPRES).
Lau PKH, Feran B, Smith L, Lasocki A, Molania R, Smith K, Weppler A, Angel C, Kee D, Bhave P, Lee B, Young RJ, Iravani A, Yeang HA, Vergara IA, Kok D, Drummond K, Neeson PJ, Sheppard KE, Papenfuss T, Solomon BJ, Sandhu S, McArthur GA. Lau PKH, et al. J Immunother Cancer. 2021 Oct;9(10):e002995. doi: 10.1136/jitc-2021-002995. J Immunother Cancer. 2021. PMID: 34625515 Free PMC article.
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma.
Smith LK, Parmenter T, Kleinschmidt M, Kusnadi EP, Kang J, Martin CA, Lau P, Patel R, Lorent J, Papadopoli D, Trigos A, Ward T, Rao AD, Lelliott EJ, Sheppard KE, Goode D, Hicks RJ, Tiganis T, Simpson KJ, Larsson O, Blythe B, Cullinane C, Wickramasinghe VO, Pearson RB, McArthur GA. Smith LK, et al. Nat Commun. 2022 Mar 1;13(1):1100. doi: 10.1038/s41467-022-28705-x. Nat Commun. 2022. PMID: 35232962 Free PMC article.
262 results