Smith E - Search Results

1

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.

Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Grandjean JMD, et al. Among authors: smith e. Nat Chem Biol. 2020 Oct;16(10):1052-1061. doi: 10.1038/s41589-020-0584-z. Epub 2020 Jul 20. Nat Chem Biol. 2020. PMID: 32690944 Free PMC article.

2

A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor.

Conn PM, Smith E, Spicer T, Chase P, Scampavia L, Janovick JA. Conn PM, et al. Among authors: smith e. Assay Drug Dev Technol. 2014 May;12(4):238-46. doi: 10.1089/adt.2014.576. Assay Drug Dev Technol. 2014. PMID: 24831790 Free PMC article.

3

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4).

Smith E, Chase P, Niswender CM, Utley TJ, Sheffler DJ, Noetzel MJ, Lamsal A, Wood MR, Conn PJ, Lindsley CW, Madoux F, Acosta M, Scampavia L, Spicer T, Hodder P. Smith E, et al. J Biomol Screen. 2015 Aug;20(7):858-68. doi: 10.1177/1087057115581770. Epub 2015 Apr 15. J Biomol Screen. 2015. PMID: 25877150 Free PMC article.

4

An Integrated Approach for Screening and Identification of Positive Allosteric Modulators of N-Methyl-D-Aspartate Receptors.

Jambrina E, Cerne R, Smith E, Scampavia L, Cuadrado M, Findlay J, Krambis MJ, Wakulchik M, Chase P, Brunavs M, Burris KD, Gallagher P, Spicer TP, Ursu D. Jambrina E, et al. Among authors: smith e. J Biomol Screen. 2016 Jun;21(5):468-79. doi: 10.1177/1087057116628437. Epub 2016 Feb 2. J Biomol Screen. 2016. PMID: 26838761

5

Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.

Smith E, Janovick JA, Bannister TD, Shumate J, Scampavia L, Conn PM, Spicer TP. Smith E, et al. J Biomol Screen. 2016 Sep;21(8):824-31. doi: 10.1177/1087057116653925. Epub 2016 Jun 8. J Biomol Screen. 2016. PMID: 27280550 Free PMC article.

6

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.

Janovick JA, Spicer TP, Smith E, Bannister TD, Kenakin T, Scampavia L, Conn PM. Janovick JA, et al. Among authors: smith e. Mol Cell Endocrinol. 2016 Oct 15;434:176-85. doi: 10.1016/j.mce.2016.07.003. Epub 2016 Jul 4. Mol Cell Endocrinol. 2016. PMID: 27389877 Free PMC article.

7

A Homogeneous Cell-Based Halide-Sensitive Yellow Fluorescence Protein Assay to Identify Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Ion Channel.

Smith E, Giuliano KA, Shumate J, Baillargeon P, McEwan B, Cullen MD, Miller JP, Drew L, Scampavia L, Spicer TP. Smith E, et al. Assay Drug Dev Technol. 2017 Dec;15(8):395-406. doi: 10.1089/adt.2017.810. Epub 2017 Nov 27. Assay Drug Dev Technol. 2017. PMID: 29172645

8

Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant.

Janovick JA, Spicer TP, Bannister TD, Smith E, Ganapathy V, Scampavia L. Janovick JA, et al. Among authors: smith e. Biochem J. 2018 Sep 25;475(18):2941-2953. doi: 10.1042/BCJ20180065. Biochem J. 2018. PMID: 30068530

9

Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins.

Zhou W, Yin Y, Smith E, Chou J, Shumate J, Scampavia L, Spicer TP, Carpino N, French JB. Zhou W, et al. Among authors: smith e. ACS Infect Dis. 2019 Feb 8;5(2):250-259. doi: 10.1021/acsinfecdis.8b00238. Epub 2018 Dec 14. ACS Infect Dis. 2019. PMID: 30485744 Free PMC article.

10

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity.

Smith E, Janovick JA, Bannister TD, Shumate J, Ganapathy V, Scampavia L, Spicer TP. Smith E, et al. Sci Rep. 2020 Jun 29;10(1):10579. doi: 10.1038/s41598-020-67473-w. Sci Rep. 2020. PMID: 32601341 Free PMC article.

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