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PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.
Rustenhoven J, Smith AM, Smyth LC, Jansson D, Scotter EL, Swanson MEV, Aalderink M, Coppieters N, Narayan P, Handley R, Overall C, Park TIH, Schweder P, Heppner P, Curtis MA, Faull RLM, Dragunow M. Rustenhoven J, et al. Among authors: smith am. Mol Neurodegener. 2018 Aug 20;13(1):44. doi: 10.1186/s13024-018-0277-1. Mol Neurodegener. 2018. PMID: 30124174 Free PMC article.
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.
Jiwaji Z, Tiwari SS, Avilés-Reyes RX, Hooley M, Hampton D, Torvell M, Johnson DA, McQueen J, Baxter P, Sabari-Sankar K, Qiu J, He X, Fowler J, Febery J, Gregory J, Rose J, Tulloch J, Loan J, Story D, McDade K, Smith AM, Greer P, Ball M, Kind PC, Matthews PM, Smith C, Dando O, Spires-Jones TL, Johnson JA, Chandran S, Hardingham GE. Jiwaji Z, et al. Among authors: smith am, smith c. Nat Commun. 2022 Jan 10;13(1):135. doi: 10.1038/s41467-021-27702-w. Nat Commun. 2022. PMID: 35013236 Free PMC article.
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Nutma E, Fancy N, Weinert M, Tsartsalis S, Marzin MC, Muirhead RCJ, Falk I, Breur M, de Bruin J, Hollaus D, Pieterman R, Anink J, Story D, Chandran S, Tang J, Trolese MC, Saito T, Saido TC, Wiltshire KH, Beltran-Lobo P, Phillips A, Antel J, Healy L, Dorion MF, Galloway DA, Benoit RY, Amossé Q, Ceyzériat K, Badina AM, Kövari E, Bendotti C, Aronica E, Radulescu CI, Wong JH, Barron AM, Smith AM, Barnes SJ, Hampton DW, van der Valk P, Jacobson S, Howell OW, Baker D, Kipp M, Kaddatz H, Tournier BB, Millet P, Matthews PM, Moore CS, Amor S, Owen DR. Nutma E, et al. Among authors: smith am. Nat Commun. 2023 Aug 28;14(1):5247. doi: 10.1038/s41467-023-40937-z. Nat Commun. 2023. PMID: 37640701 Free PMC article.
A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease.
Tsartsalis S, Sleven H, Fancy N, Wessely F, Smith AM, Willumsen N, Cheung TKD, Rokicki MJ, Chau V, Ifie E, Khozoie C, Ansorge O, Yang X, Jenkyns MH, Davey K, McGarry A, Muirhead RCJ, Debette S, Jackson JS, Montagne A, Owen DR, Miners JS, Love S, Webber C, Cader MZ, Matthews PM. Tsartsalis S, et al. Among authors: smith am. Nat Commun. 2024 Mar 12;15(1):2243. doi: 10.1038/s41467-024-46630-z. Nat Commun. 2024. PMID: 38472200 Free PMC article.
Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics.
Fancy NN, Smith AM, Caramello A, Tsartsalis S, Davey K, Muirhead RCJ, McGarry A, Jenkyns MH, Schneegans E, Chau V, Thomas M, Boulger S, Cheung TKD, Adair E, Papageorgopoulou M, Willumsen N, Khozoie C, Gomez-Nicola D, Jackson JS, Matthews PM. Fancy NN, et al. Among authors: smith am. Acta Neuropathol. 2024 May 2;147(1):78. doi: 10.1007/s00401-024-02727-9. Acta Neuropathol. 2024. PMID: 38695952 Free PMC article.
The human side of microglia.
Smith AM, Dragunow M. Smith AM, et al. Trends Neurosci. 2014 Mar;37(3):125-35. doi: 10.1016/j.tins.2013.12.001. Epub 2014 Jan 2. Trends Neurosci. 2014. PMID: 24388427 Review.
Response to Watkins and Hutchinson.
Smith AM, Dragunow M. Smith AM, et al. Trends Neurosci. 2014 Apr;37(4):190. doi: 10.1016/j.tins.2014.02.005. Epub 2014 Mar 11. Trends Neurosci. 2014. PMID: 24630097 No abstract available.
Isolation of highly enriched primary human microglia for functional studies.
Rustenhoven J, Park TI, Schweder P, Scotter J, Correia J, Smith AM, Gibbons HM, Oldfield RL, Bergin PS, Mee EW, Faull RL, Curtis MA, Scott Graham E, Dragunow M. Rustenhoven J, et al. Among authors: smith am. Sci Rep. 2016 Jan 18;6:19371. doi: 10.1038/srep19371. Sci Rep. 2016. PMID: 26778406 Free PMC article.
1,935 results