Smit L - Search Results

1

Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters.

van Gils N, Verhagen HJMP, Broux M, Martiáñez T, Denkers F, Vermue E, Rutten A, Csikós T, Demeyer S, Çil M, Al M, Cools J, Janssen JJWM, Ossenkoppele GJ, Menezes RX, Smit L. van Gils N, et al. Among authors: smit l. iScience. 2022 Aug 25;25(9):105013. doi: 10.1016/j.isci.2022.105013. eCollection 2022 Sep 16. iScience. 2022. PMID: 36097617 Free PMC article.

2

MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia.

de Leeuw DC, van den Ancker W, Denkers F, de Menezes RX, Westers TM, Ossenkoppele GJ, van de Loosdrecht AA, Smit L. de Leeuw DC, et al. Among authors: smit l. Clin Cancer Res. 2013 Apr 15;19(8):2187-96. doi: 10.1158/1078-0432.CCR-12-3657. Epub 2013 Feb 26. Clin Cancer Res. 2013. PMID: 23444217

3

Normal hematopoietic stem cells within the AML bone marrow have a distinct and higher ALDH activity level than co-existing leukemic stem cells.

Schuurhuis GJ, Meel MH, Wouters F, Min LA, Terwijn M, de Jonge NA, Kelder A, Snel AN, Zweegman S, Ossenkoppele GJ, Smit L. Schuurhuis GJ, et al. Among authors: smit l. PLoS One. 2013 Nov 11;8(11):e78897. doi: 10.1371/journal.pone.0078897. eCollection 2013. PLoS One. 2013. PMID: 24244383 Free PMC article. Clinical Trial.

4

Attenuation of microRNA-126 expression that drives CD34+38- stem/progenitor cells in acute myeloid leukemia leads to tumor eradication.

de Leeuw DC, Denkers F, Olthof MC, Rutten AP, Pouwels W, Schuurhuis GJ, Ossenkoppele GJ, Smit L. de Leeuw DC, et al. Among authors: smit l. Cancer Res. 2014 Apr 1;74(7):2094-105. doi: 10.1158/0008-5472.CAN-13-1733. Epub 2014 Jan 29. Cancer Res. 2014. PMID: 24477595

5

IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival.

Verhagen HJ, de Leeuw DC, Roemer MG, Denkers F, Pouwels W, Rutten A, Celie PH, Ossenkoppele GJ, Schuurhuis GJ, Smit L. Verhagen HJ, et al. Among authors: smit l. Cell Death Dis. 2014 Jun 26;5(6):e1300. doi: 10.1038/cddis.2014.268. Cell Death Dis. 2014. PMID: 24967962 Free PMC article.

6

MicroRNA-551b is highly expressed in hematopoietic stem cells and a biomarker for relapse and poor prognosis in acute myeloid leukemia.

de Leeuw DC, Verhagen HJ, Denkers F, Kavelaars FG, Valk PJ, Schuurhuis GJ, Ossenkoppele GJ, Smit L. de Leeuw DC, et al. Among authors: smit l. Leukemia. 2016 Mar;30(3):742-6. doi: 10.1038/leu.2015.160. Epub 2015 Jun 25. Leukemia. 2016. PMID: 26108690 No abstract available.

7

Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid.

Verhagen HJ, Smit MA, Rutten A, Denkers F, Poddighe PJ, Merle PA, Ossenkoppele GJ, Smit L. Verhagen HJ, et al. Among authors: smit ma, smit l. Blood. 2016 Jan 28;127(4):458-63. doi: 10.1182/blood-2015-07-653840. Epub 2015 Nov 18. Blood. 2016. PMID: 26582376 Free article.

8

Reprogramming acute myeloid leukemia into sensitivity for retinoic-acid-driven differentiation.

van Gils N, Verhagen HJMP, Smit L. van Gils N, et al. Among authors: smit l. Exp Hematol. 2017 Aug;52:12-23. doi: 10.1016/j.exphem.2017.04.007. Epub 2017 Apr 27. Exp Hematol. 2017. PMID: 28456748 Free article. Review.

9

Specific Depletion of Leukemic Stem Cells: Can MicroRNAs Make the Difference?

Martiáñez Canales T, de Leeuw DC, Vermue E, Ossenkoppele GJ, Smit L. Martiáñez Canales T, et al. Among authors: smit l. Cancers (Basel). 2017 Jun 30;9(7):74. doi: 10.3390/cancers9070074. Cancers (Basel). 2017. PMID: 28665351 Free PMC article. Review.

10

VEGFC Antibody Therapy Drives Differentiation of AML.

Kampen KR, Scherpen FJG, Mahmud H, Ter Elst A, Mulder AB, Guryev V, Verhagen HJMP, De Keersmaecker K, Smit L, Kornblau SM, De Bont ESJM. Kampen KR, et al. Among authors: smit l. Cancer Res. 2018 Oct 15;78(20):5940-5948. doi: 10.1158/0008-5472.CAN-18-0250. Epub 2018 Sep 5. Cancer Res. 2018. PMID: 30185550

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