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LC-MS/MS-based quantification of efflux transporter proteins at the BBB.
Gomez-Zepeda D, Taghi M, Smirnova M, Sergent P, Liu WQ, Chhuon C, Vidal M, Picard M, Thioulouse E, Broutin I, Guerrera IC, Scherrmann JM, Parmentier Y, Decleves X, Menet MC. Gomez-Zepeda D, et al. Among authors: smirnova m. J Pharm Biomed Anal. 2019 Feb 5;164:496-508. doi: 10.1016/j.jpba.2018.11.013. Epub 2018 Nov 8. J Pharm Biomed Anal. 2019. PMID: 30453156
Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice.
Alhaddad H, Cisternino S, Declèves X, Tournier N, Schlatter J, Chiadmi F, Risède P, Smirnova M, Besengez C, Scherrmann JM, Baud FJ, Mégarbane B. Alhaddad H, et al. Among authors: smirnova m. Crit Care Med. 2012 Dec;40(12):3215-23. doi: 10.1097/CCM.0b013e318265680a. Crit Care Med. 2012. PMID: 22975888
Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties.
Seleman M, Chapy H, Cisternino S, Courtin C, Smirnova M, Schlatter J, Chiadmi F, Scherrmann JM, Noble F, Marie-Claire C. Seleman M, et al. Among authors: smirnova m. Psychopharmacology (Berl). 2014 Aug;231(16):3139-49. doi: 10.1007/s00213-014-3490-9. Epub 2014 Apr 5. Psychopharmacology (Berl). 2014. PMID: 24705903
Diphenhydramine as a selective probe to study H+-antiporter function at the blood-brain barrier: Application to [11C]diphenhydramine positron emission tomography imaging.
Auvity S, Chapy H, Goutal S, Caillé F, Hosten B, Smirnova M, Declèves X, Tournier N, Cisternino S. Auvity S, et al. Among authors: smirnova m. J Cereb Blood Flow Metab. 2017 Jun;37(6):2185-2195. doi: 10.1177/0271678X16662042. Epub 2016 Jan 1. J Cereb Blood Flow Metab. 2017. PMID: 27488910 Free PMC article.
High brain distribution of a new central nervous system drug candidate despite its P-glycoprotein-mediated efflux at the mouse blood-brain barrier.
Taccola C, Cartot-Cotton S, Valente D, Barneoud P, Aubert C, Boutet V, Gallen F, Lochus M, Nicolic S, Dodacki A, Smirnova M, Cisternino S, Declèves X, Bourasset F. Taccola C, et al. Among authors: smirnova m. Eur J Pharm Sci. 2018 May 30;117:68-79. doi: 10.1016/j.ejps.2018.02.005. Epub 2018 Feb 7. Eur J Pharm Sci. 2018. PMID: 29427702
294 results