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Hydrogen sulfide dysfunction in metabolic syndrome-associated vascular complications involves cGMP regulation through soluble guanylyl cyclase persulfidation.
Smimmo M, Casale V, Casillo GM, Mitidieri E, d'Emmanuele di Villa Bianca R, Bello I, Schettino A, Montanaro R, Brancaleone V, Indolfi C, Cirino G, Di Lorenzo A, Bucci M, Panza E, Vellecco V. Smimmo M, et al. Biomed Pharmacother. 2024 May;174:116466. doi: 10.1016/j.biopha.2024.116466. Epub 2024 Mar 28. Biomed Pharmacother. 2024. PMID: 38552439 Free article.
A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease.
Saviano A, Schettino A, Iaccarino N, Mansour AA, Begum J, Marigliano N, Raucci F, Romano F, Riccardi G, Mitidieri E, d'Emmanuele di Villa Bianca R, Bello I, Panza E, Smimmo M, Vellecco V, Rimmer P, Cheesbrough J, Zhi Z, Iqbal TH, Pieretti S, D'Amore VM, Marinelli L, La Pietra V, Sorrentino R, Costa L, Caso F, Scarpa R, Cirino G, Randazzo A, Bucci M, McGettrick HM, Iqbal AJ, Maione F. Saviano A, et al. Among authors: smimmo m. J Autoimmun. 2024 Apr;144:103181. doi: 10.1016/j.jaut.2024.103181. Epub 2024 Mar 23. J Autoimmun. 2024. PMID: 38522129
Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway.
Montanaro R, Vellecco V, Torregrossa R, Casillo GM, Manzo OL, Mitidieri E, Bucci M, Castaldo S, Sorrentino R, Whiteman M, Smimmo M, Carriero F, Terrazzano G, Cirino G, d'Emmanuele di Villa Bianca R, Brancaleone V. Montanaro R, et al. Among authors: smimmo m. Redox Biol. 2023 Jun;62:102657. doi: 10.1016/j.redox.2023.102657. Epub 2023 Mar 4. Redox Biol. 2023. PMID: 36913800 Free PMC article.
Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio.
Saviano A, Raucci F, Casillo GM, Mansour AA, Piccolo V, Montesano C, Smimmo M, Vellecco V, Capasso G, Boscaino A, Summa V, Mascolo N, Iqbal AJ, Sorrentino R, d'Emmanuele di Villa Bianca R, Bucci M, Brancaleone V, Maione F. Saviano A, et al. Among authors: smimmo m. Pharmacol Res. 2022 Aug;182:106283. doi: 10.1016/j.phrs.2022.106283. Epub 2022 Jun 1. Pharmacol Res. 2022. PMID: 35662629
Phosphodiesterases S-sulfhydration contributes to human skeletal muscle function.
Vellecco V, Panza E, Bibli SI, Casillo GM, Raucci F, Manzo OL, Smimmo M, Villani R, Cavezza MR, Fleming I, d'Emmanuele di Villa Bianca R, Maione F, Cirino G, Bucci M. Vellecco V, et al. Among authors: smimmo m. Pharmacol Res. 2022 Mar;177:106108. doi: 10.1016/j.phrs.2022.106108. Epub 2022 Feb 1. Pharmacol Res. 2022. PMID: 35121122
Duchenne's muscular dystrophy involves a defective transsulfuration pathway activity.
Panza E, Vellecco V, Iannotti FA, Paris D, Manzo OL, Smimmo M, Mitilini N, Boscaino A, de Dominicis G, Bucci M, Di Lorenzo A, Cirino G. Panza E, et al. Among authors: smimmo m. Redox Biol. 2021 Sep;45:102040. doi: 10.1016/j.redox.2021.102040. Epub 2021 Jun 19. Redox Biol. 2021. PMID: 34174560 Free PMC article.