Phosphotyrosine phosphatase inhibitor bisperoxovanadium endows myogenic cells with enhanced muscle stem cell functions via epigenetic modulation of Sca-1 and Pw1 promoters.
Smeriglio P, Alonso-Martin S, Masciarelli S, Madaro L, Iosue I, Marrocco V, Relaix F, Fazi F, Marazzi G, Sassoon DA, Bouché M.
Smeriglio P, et al.
FASEB J. 2016 Apr;30(4):1404-15. doi: 10.1096/fj.15-275420. Epub 2015 Dec 15.
FASEB J. 2016.
PMID: 26672000
Moreover, we found that BpV treatment induces specific activating chromatin modifications at the promoter regions of genes associated with stem cell fate, includingSca-1andPw1 Thus, our findings indicate that BpV resets the cell fate program by specific epigenetic regulations, su …
Moreover, we found that BpV treatment induces specific activating chromatin modifications at the promoter regions of genes associated with s …