Slynko I - Search Results

1

Application of docking and QM/MM-GBSA rescoring to screen for novel Myt1 kinase inhibitors.

Wichapong K, Rohe A, Platzer C, Slynko I, Erdmann F, Schmidt M, Sippl W. Wichapong K, et al. Among authors: slynko i. J Chem Inf Model. 2014 Mar 24;54(3):881-93. doi: 10.1021/ci4007326. Epub 2014 Feb 13. J Chem Inf Model. 2014. PMID: 24490903

2

Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development.

Slynko I, Scharfe M, Rumpf T, Eib J, Metzger E, Schüle R, Jung M, Sippl W. Slynko I, et al. J Chem Inf Model. 2014 Jan 27;54(1):138-50. doi: 10.1021/ci400628q. Epub 2014 Jan 8. J Chem Inf Model. 2014. PMID: 24377786

3

Discovery of 4-anilino α-carbolines as novel Brk inhibitors.

Mahmoud KA, Krug M, Wersig T, Slynko I, Schächtele C, Totzke F, Sippl W, Hilgeroth A. Mahmoud KA, et al. Among authors: slynko i. Bioorg Med Chem Lett. 2014 Apr 15;24(8):1948-51. doi: 10.1016/j.bmcl.2014.03.002. Epub 2014 Mar 12. Bioorg Med Chem Lett. 2014. PMID: 24650640

4

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing.

Slynko I, Schmidtkunz K, Rumpf T, Klaeger S, Heinzlmeir S, Najar A, Metzger E, Kuster B, Schüle R, Jung M, Sippl W. Slynko I, et al. ChemMedChem. 2016 Sep 20;11(18):2084-94. doi: 10.1002/cmdc.201600284. Epub 2016 Jul 29. ChemMedChem. 2016. PMID: 27472906

5

Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach.

Tell V, Hilbrich I, Holzer M, Totzke F, Schachtele C, Slynko I, Sippl W, Hilgeroth A. Tell V, et al. Among authors: slynko i. Curr Alzheimer Res. 2016;13(12):1330-1336. doi: 10.2174/1567205013666160615091821. Curr Alzheimer Res. 2016. PMID: 27306698 Review.

6

Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).

Ostrovskyi D, Rumpf T, Eib J, Lumbroso A, Slynko I, Klaeger S, Heinzlmeir S, Forster M, Gehringer M, Pfaffenrot E, Bauer SM, Schmidtkunz K, Wenzler S, Metzger E, Kuster B, Laufer S, Schüle R, Sippl W, Breit B, Jung M. Ostrovskyi D, et al. Among authors: slynko i. Future Med Chem. 2016 Sep;8(13):1537-51. doi: 10.4155/fmc-2016-0132. Epub 2016 Aug 30. Future Med Chem. 2016. PMID: 27572962

7

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.

Köhler J, Erlenkamp G, Eberlin A, Rumpf T, Slynko I, Metzger E, Schüle R, Sippl W, Jung M. Köhler J, et al. Among authors: slynko i. PLoS One. 2012;7(4):e34973. doi: 10.1371/journal.pone.0034973. Epub 2012 Apr 20. PLoS One. 2012. PMID: 22532837 Free PMC article.

8

Docking pose selection by interaction pattern graph similarity: application to the D3R grand challenge 2015.

Slynko I, Da Silva F, Bret G, Rognan D. Slynko I, et al. J Comput Aided Mol Des. 2016 Sep;30(9):669-683. doi: 10.1007/s10822-016-9930-3. Epub 2016 Aug 1. J Comput Aided Mol Des. 2016. PMID: 27480696

9

Covalent Inhibition of the Histamine H₃ Receptor.

Wágner G, Mocking TAM, Kooistra AJ, Slynko I, Ábrányi-Balogh P, Keserű GM, Wijtmans M, Vischer HF, de Esch IJP, Leurs R. Wágner G, et al. Among authors: slynko i. Molecules. 2019 Dec 11;24(24):4541. doi: 10.3390/molecules24244541. Molecules. 2019. PMID: 31835873 Free PMC article.

10

Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations.

Slynko I, Nguyen S, Hamilton EMC, Wisse LE, de Esch IJP, de Graaf C, Bruning JB, Proud CG, Abbink TEM, van der Knaap MS. Slynko I, et al. Mol Genet Genomic Med. 2021 Mar;9(3):e1593. doi: 10.1002/mgg3.1593. Epub 2021 Jan 12. Mol Genet Genomic Med. 2021. PMID: 33432707 Free PMC article.

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