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Glutamine antagonism attenuates physical and cognitive deficits in a model of MS.
Hollinger KR, Smith MD, Kirby LA, Prchalova E, Alt J, Rais R, Calabresi PA, Slusher BS. Hollinger KR, et al. Among authors: slusher bs. Neurol Neuroimmunol Neuroinflamm. 2019 Aug 29;6(6):e609. doi: 10.1212/NXI.0000000000000609. Print 2019 Nov. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 31467038 Free PMC article.
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.
Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Leone RD, et al. Among authors: slusher bs. Science. 2019 Nov 22;366(6468):1013-1021. doi: 10.1126/science.aav2588. Epub 2019 Nov 7. Science. 2019. PMID: 31699883 Free PMC article.
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.
Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, Collins SL, Tam AJ, Blosser RL, Patel CH, Englert JM, Arwood ML, Wen J, Chan-Li Y, Tenora L, Majer P, Rais R, Slusher BS, Horton MR, Powell JD. Oh MH, et al. Among authors: slusher bs. J Clin Invest. 2020 Jul 1;130(7):3865-3884. doi: 10.1172/JCI131859. J Clin Invest. 2020. PMID: 32324593 Free PMC article.
Preventing Allograft Rejection by Targeting Immune Metabolism.
Lee CF, Lo YC, Cheng CH, Furtmüller GJ, Oh B, Andrade-Oliveira V, Thomas AG, Bowman CE, Slusher BS, Wolfgang MJ, Brandacher G, Powell JD. Lee CF, et al. Among authors: slusher bs. Cell Rep. 2015 Oct 27;13(4):760-770. doi: 10.1016/j.celrep.2015.09.036. Epub 2015 Oct 17. Cell Rep. 2015. PMID: 26489460 Free PMC article.
Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders.
Nedelcovych MT, Kim BH, Zhu X, Lovell LE, Manning AA, Kelschenbach J, Hadas E, Chao W, Prchalová E, Dash RP, Wu Y, Alt J, Thomas AG, Rais R, Kamiya A, Volsky DJ, Slusher BS. Nedelcovych MT, et al. Among authors: slusher bs. J Neuroimmune Pharmacol. 2019 Sep;14(3):391-400. doi: 10.1007/s11481-019-09859-w. Epub 2019 Jun 17. J Neuroimmune Pharmacol. 2019. PMID: 31209775 Free PMC article.
Clinical development of metabolic inhibitors for oncology.
Lemberg KM, Gori SS, Tsukamoto T, Rais R, Slusher BS. Lemberg KM, et al. Among authors: slusher bs. J Clin Invest. 2022 Jan 4;132(1):e148550. doi: 10.1172/JCI148550. J Clin Invest. 2022. PMID: 34981784 Free PMC article. Review.
Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Rais R, Lemberg KM, Tenora L, Arwood ML, Pal A, Alt J, Wu Y, Lam J, Aguilar JMH, Zhao L, Peters DE, Tallon C, Pandey R, Thomas AG, Dash RP, Seiwert T, Majer P, Leone RD, Powell JD, Slusher BS. Rais R, et al. Among authors: slusher bs. Sci Adv. 2022 Nov 18;8(46):eabq5925. doi: 10.1126/sciadv.abq5925. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383674 Free PMC article.
287 results