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Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity.
Akbari P, Gilani A, Sosina O, Kosmicki JA, Khrimian L, Fang YY, Persaud T, Garcia V, Sun D, Li A, Mbatchou J, Locke AE, Benner C, Verweij N, Lin N, Hossain S, Agostinucci K, Pascale JV, Dirice E, Dunn M; Regeneron Genetics Center; DiscovEHR Collaboration; Kraus WE, Shah SH, Chen YI, Rotter JI, Rader DJ, Melander O, Still CD, Mirshahi T, Carey DJ, Berumen-Campos J, Kuri-Morales P, Alegre-Díaz J, Torres JM, Emberson JR, Collins R, Balasubramanian S, Hawes A, Jones M, Zambrowicz B, Murphy AJ, Paulding C, Coppola G, Overton JD, Reid JG, Shuldiner AR, Cantor M, Kang HM, Abecasis GR, Karalis K, Economides AN, Marchini J, Yancopoulos GD, Sleeman MW, Altarejos J, Della Gatta G, Tapia-Conyer R, Schwartzman ML, Baras A, Ferreira MAR, Lotta LA. Akbari P, et al. Among authors: sleeman mw. Science. 2021 Jul 2;373(6550):eabf8683. doi: 10.1126/science.abf8683. Science. 2021. PMID: 34210852 Free PMC article.
Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity.
Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ. Lambert PD, et al. Among authors: sleeman mw. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4652-7. doi: 10.1073/pnas.061034298. Epub 2001 Mar 20. Proc Natl Acad Sci U S A. 2001. PMID: 11259650 Free PMC article.
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.
Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, Murphy AJ. Macdonald LE, et al. Among authors: sleeman mw. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501. doi: 10.1073/pnas.0409849102. Epub 2005 Feb 7. Proc Natl Acad Sci U S A. 2005. PMID: 15699348 Free PMC article.
Agouti-related protein-deficient mice display an age-related lean phenotype.
Wortley KE, Anderson KD, Yasenchak J, Murphy A, Valenzuela D, Diano S, Yancopoulos GD, Wiegand SJ, Sleeman MW. Wortley KE, et al. Among authors: sleeman mw. Cell Metab. 2005 Dec;2(6):421-7. doi: 10.1016/j.cmet.2005.11.004. Cell Metab. 2005. PMID: 16330327 Free article.
Peptide YY regulates bone turnover in rodents.
Wortley KE, Garcia K, Okamoto H, Thabet K, Anderson KD, Shen V, Herman JP, Valenzuela D, Yancopoulos GD, Tschöp MH, Murphy A, Sleeman MW. Wortley KE, et al. Among authors: sleeman mw. Gastroenterology. 2007 Nov;133(5):1534-43. doi: 10.1053/j.gastro.2007.08.024. Epub 2007 Aug 15. Gastroenterology. 2007. PMID: 17920065
70 results