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Page 1
Targeting malaria parasites with novel derivatives of azithromycin.
Burns AL, Sleebs BE, Gancheva M, McLean KT, Siddiqui G, Venter H, Beeson JG, O'Handley R, Creek DJ, Ma S, Frölich S, Goodman CD, McFadden GI, Wilson DW. Burns AL, et al. Among authors: sleebs be. Front Cell Infect Microbiol. 2022 Nov 30;12:1063407. doi: 10.3389/fcimb.2022.1063407. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36530422 Free PMC article.
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE. Gilson PR, et al. Among authors: sleebs be. J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26. J Med Chem. 2017. PMID: 28080063
Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SHW, Baum J. Wong W, et al. Among authors: sleebs be. Nat Microbiol. 2017 Mar 13;2:17031. doi: 10.1038/nmicrobiol.2017.31. Nat Microbiol. 2017. PMID: 28288098 Free PMC article.
Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.
Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE. Gilson PR, et al. Among authors: sleebs be. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar. Antimicrob Agents Chemother. 2019. PMID: 30559138 Free PMC article.
Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle.
Favuzza P, de Lera Ruiz M, Thompson JK, Triglia T, Ngo A, Steel RWJ, Vavrek M, Christensen J, Healer J, Boyce C, Guo Z, Hu M, Khan T, Murgolo N, Zhao L, Penington JS, Reaksudsan K, Jarman K, Dietrich MH, Richardson L, Guo KY, Lopaticki S, Tham WH, Rottmann M, Papenfuss T, Robbins JA, Boddey JA, Sleebs BE, Sabroux HJ, McCauley JA, Olsen DB, Cowman AF. Favuzza P, et al. Among authors: sleebs be. Cell Host Microbe. 2020 Apr 8;27(4):642-658.e12. doi: 10.1016/j.chom.2020.02.005. Epub 2020 Feb 27. Cell Host Microbe. 2020. PMID: 32109369 Free PMC article.
Retargeting azithromycin analogues to have dual-modality antimalarial activity.
Burns AL, Sleebs BE, Siddiqui G, De Paoli AE, Anderson D, Liffner B, Harvey R, Beeson JG, Creek DJ, Goodman CD, McFadden GI, Wilson DW. Burns AL, et al. Among authors: sleebs be. BMC Biol. 2020 Sep 29;18(1):133. doi: 10.1186/s12915-020-00859-4. BMC Biol. 2020. PMID: 32993629 Free PMC article.
74 results