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TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.
Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P. Wolczyk M, et al. Among authors: skorski t. iScience. 2023 Mar 31;26(4):106543. doi: 10.1016/j.isci.2023.106543. eCollection 2023 Apr 21. iScience. 2023. PMID: 37123244 Free PMC article.
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Fried W, Tyagi M, Minakhin L, Chandramouly G, Tredinnick T, Ramanjulu M, Auerbacher W, Calbert M, Rusanov T, Hoang T, Borisonnik N, Betsch R, Krais JJ, Wang Y, Vekariya UM, Gordon J, Morton G, Kent T, Skorski T, Johnson N, Childers W, Chen XS, Pomerantz RT. Fried W, et al. Among authors: skorski t. Nat Commun. 2024 Apr 5;15(1):2862. doi: 10.1038/s41467-024-46593-1. Nat Commun. 2024. PMID: 38580648 Free PMC article.
Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours.
Barszczewska-Pietraszek G, Drzewiecka M, Czarny P, Skorski T, Śliwiński T. Barszczewska-Pietraszek G, et al. Among authors: skorski t. Int J Mol Sci. 2022 Dec 24;24(1):319. doi: 10.3390/ijms24010319. Int J Mol Sci. 2022. PMID: 36613762 Free PMC article. Review.
Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement.
Gray ZH, Chakraborty D, Duttweiler RR, Alekbaeva GD, Murphy SE, Chetal K, Ji F, Ferman BI, Honer MA, Wang Z, Myers C, Sun R, Kaniskan HÜ, Toma MM, Bondarenko EA, Santoro JN, Miranda C, Dillingham ME, Tang R, Gozani O, Jin J, Skorski T, Duy C, Lee H, Sadreyev RI, Whetstine JR. Gray ZH, et al. Among authors: skorski t. Cell. 2023 Oct 12;186(21):4528-4545.e18. doi: 10.1016/j.cell.2023.09.009. Epub 2023 Oct 2. Cell. 2023. PMID: 37788669
Clonal medicine targeting DNA damage response eradicates leukemia.
Toma MM, Karami A, Nieborowska-Skorska M, Chirtala KN, Pepek M, Hadzijusufovic E, Stoklosa T, Valent P, Skorski T. Toma MM, et al. Among authors: skorski t. Leukemia. 2024 Mar;38(3):671-675. doi: 10.1038/s41375-024-02138-5. Epub 2024 Jan 16. Leukemia. 2024. PMID: 38228681 Free PMC article. No abstract available.
206 results