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Prothymosin α and its C-Terminal Immunoreactive Decapeptide Show No Evidence of Acute Toxicity: A Preliminary In Silico, In Vitro and In Vivo Investigation.
Birmpilis AI, Vitsos P, Kostopoulos IV, Williams L, Ioannou K, Samara P, Karachaliou CE, Voutsas IF, Alyfanti E, Angelis N, Gavalas NG, Gkraikou T, Kappa N, Klagkou E, Klimentzou P, Nikou S, Papaioannou NE, Skopeliti M, Toukli D, Dimopoulos MA, Bamias A, Livaniou E, Kalbacher H, Tsitsilonis OE, Voelter W. Birmpilis AI, et al. Among authors: skopeliti m. Curr Med Chem. 2022;29(42):6463-6478. doi: 10.2174/0929867328666211117093401. Curr Med Chem. 2022. PMID: 34789121
The immunologically active site of prothymosin alpha is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients.
Skopeliti M, Voutsas IF, Klimentzou P, Tsiatas ML, Beck A, Bamias A, Moraki M, Livaniou E, Neagu M, Voelter W, Tsitsilonis OE. Skopeliti M, et al. Cancer Immunol Immunother. 2006 Oct;55(10):1247-57. doi: 10.1007/s00262-005-0108-4. Epub 2006 Feb 2. Cancer Immunol Immunother. 2006. PMID: 16453152 Free PMC article.
Ovarian malignant ascites-derived lymphocytes stimulated with prothymosin α or its immunoactive decapeptide lyse autologous tumour cells in vitro and retard tumour growth in SCID mice.
Voutsas IF, Pistamaltzian N, Tsiatas ML, Skopeliti M, Katsila T, Mavrothalassiti I, Spyrou S, Dimopoulos MA, Tsitsilonis OE, Bamias A. Voutsas IF, et al. Among authors: skopeliti m. Eur J Cancer. 2013 May;49(7):1706-14. doi: 10.1016/j.ejca.2012.11.037. Epub 2012 Dec 28. Eur J Cancer. 2013. PMID: 23276721
Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner.
Skopeliti M, Iconomidou VA, Derhovanessian E, Pawelec G, Voelter W, Kalbacher H, Hamodrakas SJ, Tsitsilonis OE. Skopeliti M, et al. Mol Immunol. 2009 Feb;46(5):784-92. doi: 10.1016/j.molimm.2008.09.014. Epub 2008 Oct 30. Mol Immunol. 2009. PMID: 18976813
15 results