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Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
J Med Chem. 2007 Nov 29;50(24):5886-9. doi: 10.1021/jm070708p. Epub 2007 Nov 8.
J Med Chem. 2007.
PMID: 17988109
In vitro and in vivo activities of PD 0305970 and PD 0326448, new bacterial gyrase/topoisomerase inhibitors with potent antibacterial activities versus multidrug-resistant gram-positive and fastidious organism groups.
Huband MD, Cohen MA, Zurack M, Hanna DL, Skerlos LA, Sulavik MC, Gibson GW, Gage JW, Ellsworth E, Stier MA, Gracheck SJ.
Huband MD, et al. Among authors: skerlos la.
Antimicrob Agents Chemother. 2007 Apr;51(4):1191-201. doi: 10.1128/AAC.01321-06. Epub 2007 Jan 29.
Antimicrob Agents Chemother. 2007.
PMID: 17261623
Free PMC article.
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A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore.
Miller JR, Dunham S, Mochalkin I, Banotai C, Bowman M, Buist S, Dunkle B, Hanna D, Harwood HJ, Huband MD, Karnovsky A, Kuhn M, Limberakis C, Liu JY, Mehrens S, Mueller WT, Narasimhan L, Ogden A, Ohren J, Prasad JV, Shelly JA, Skerlos L, Sulavik M, Thomas VH, VanderRoest S, Wang L, Wang Z, Whitton A, Zhu T, Stover CK.
Miller JR, et al. Among authors: skerlos l.
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1737-42. doi: 10.1073/pnas.0811275106. Epub 2009 Jan 22.
Proc Natl Acad Sci U S A. 2009.
PMID: 19164768
Free PMC article.
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Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations.
Tsuji BT, Bulitta JB, Brown T, Forrest A, Kelchlin PA, Holden PN, Peloquin CA, Skerlos L, Hanna D.
Tsuji BT, et al. Among authors: skerlos l.
J Antimicrob Chemother. 2012 Sep;67(9):2182-90. doi: 10.1093/jac/dks201. Epub 2012 Jun 8.
J Antimicrob Chemother. 2012.
PMID: 22685161
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Comparative microbial diversity in the gastrointestinal tracts of food animal species.
Simpson JM, Kocherginskaya SA, Aminov RI, Skerlos LT, Bradley TM, Mackie RI, White BA.
Simpson JM, et al. Among authors: skerlos lt.
Integr Comp Biol. 2002 Apr;42(2):327-31. doi: 10.1093/icb/42.2.327.
Integr Comp Biol. 2002.
PMID: 21708725
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