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5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals.
Sisignano M, Park CK, Angioni C, Zhang DD, von Hehn C, Cobos EJ, Ghasemlou N, Xu ZZ, Kumaran V, Lu R, Grant A, Fischer MJ, Schmidtko A, Reeh P, Ji RR, Woolf CJ, Geisslinger G, Scholich K, Brenneis C. Sisignano M, et al. J Neurosci. 2012 May 2;32(18):6364-72. doi: 10.1523/JNEUROSCI.5793-11.2012. J Neurosci. 2012. PMID: 22553041 Free PMC article.
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.
Sisignano M, Angioni C, Park CK, Meyer Dos Santos S, Jordan H, Kuzikov M, Liu D, Zinn S, Hohman SW, Schreiber Y, Zimmer B, Schmidt M, Lu R, Suo J, Zhang DD, Schäfer SM, Hofmann M, Yekkirala AS, de Bruin N, Parnham MJ, Woolf CJ, Ji RR, Scholich K, Geisslinger G. Sisignano M, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12544-12549. doi: 10.1073/pnas.1613246113. Epub 2016 Oct 17. Proc Natl Acad Sci U S A. 2016. PMID: 27791151 Free PMC article.
The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons.
Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, Suo J, Treutlein EM, Angioni C, Ferreiros N, Leffler A, DeBruin N, Offermanns S, Geisslinger G, Scholich K. Zinn S, et al. Among authors: sisignano m. J Biol Chem. 2017 Apr 14;292(15):6123-6134. doi: 10.1074/jbc.M116.769125. Epub 2017 Feb 27. J Biol Chem. 2017. PMID: 28242764 Free PMC article.
Proton-Sensing GPCRs in Health and Disease.
Sisignano M, Fischer MJM, Geisslinger G. Sisignano M, et al. Cells. 2021 Aug 10;10(8):2050. doi: 10.3390/cells10082050. Cells. 2021. PMID: 34440817 Free PMC article. Review.
43 results