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Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects.
Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4158-4168. doi: 10.1073/pnas.1917938117. Epub 2020 Feb 12.
Proc Natl Acad Sci U S A. 2020.
PMID: 32051246
Free PMC article.
Myoepithelial cells are a dynamic barrier to epithelial dissemination.
Sirka OK, Shamir ER, Ewald AJ.
Sirka OK, et al.
J Cell Biol. 2018 Oct 1;217(10):3368-3381. doi: 10.1083/jcb.201802144. Epub 2018 Jul 30.
J Cell Biol. 2018.
PMID: 30061105
Free PMC article.
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Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling.
Georgess D, Padmanaban V, Sirka OK, Coutinho K, Choi A, Frid G, Neumann NM, Inoue T, Ewald AJ.
Georgess D, et al. Among authors: sirka ok.
Cancer Res. 2020 Jan 15;80(2):204-218. doi: 10.1158/0008-5472.CAN-18-3241. Epub 2019 Nov 1.
Cancer Res. 2020.
PMID: 31676574
Free PMC article.
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Tumor-Resident Stromal Cells Promote Breast Cancer Invasion through Regulation of the Basal Phenotype.
Hanley CJ, Henriet E, Sirka OK, Thomas GJ, Ewald AJ.
Hanley CJ, et al. Among authors: sirka ok.
Mol Cancer Res. 2020 Nov;18(11):1615-1622. doi: 10.1158/1541-7786.MCR-20-0334. Epub 2020 Aug 31.
Mol Cancer Res. 2020.
PMID: 32868298
Free PMC article.
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