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Development and Validation of a Phenotypic High-Content Imaging Assay for Assessing the Antiviral Activity of Small-Molecule Inhibitors Targeting Zika Virus.
Bernatchez JA, Yang Z, Coste M, Li J, Beck S, Liu Y, Clark AE, Zhu Z, Luna LA, Sohl CD, Purse BW, Li R, Siqueira-Neto JL. Bernatchez JA, et al. Antimicrob Agents Chemother. 2018 Sep 24;62(10):e00725-18. doi: 10.1128/AAC.00725-18. Print 2018 Oct. Antimicrob Agents Chemother. 2018. PMID: 30061280 Free PMC article.
Cysteine proteases in protozoan parasites.
Siqueira-Neto JL, Debnath A, McCall LI, Bernatchez JA, Ndao M, Reed SL, Rosenthal PJ. Siqueira-Neto JL, et al. PLoS Negl Trop Dis. 2018 Aug 23;12(8):e0006512. doi: 10.1371/journal.pntd.0006512. eCollection 2018 Aug. PLoS Negl Trop Dis. 2018. PMID: 30138453 Free PMC article. Review.
Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma.
Mack SC, Singh I, Wang X, Hirsch R, Wu Q, Villagomez R, Bernatchez JA, Zhu Z, Gimple RC, Kim LJY, Morton A, Lai S, Qiu Z, Prager BC, Bertrand KC, Mah C, Zhou W, Lee C, Barnett GH, Vogelbaum MA, Sloan AE, Chavez L, Bao S, Scacheri PC, Siqueira-Neto JL, Lin CY, Rich JN. Mack SC, et al. J Exp Med. 2019 May 6;216(5):1071-1090. doi: 10.1084/jem.20190196. Epub 2019 Apr 4. J Exp Med. 2019. PMID: 30948495 Free PMC article.
Mechanism of Action of Methotrexate Against Zika Virus.
Beck S, Zhu Z, Oliveira MF, Smith DM, Rich JN, Bernatchez JA, Siqueira-Neto JL. Beck S, et al. Viruses. 2019 Apr 10;11(4):338. doi: 10.3390/v11040338. Viruses. 2019. PMID: 30974762 Free PMC article.
Drugs for the Treatment of Zika Virus Infection.
Bernatchez JA, Tran LT, Li J, Luan Y, Siqueira-Neto JL, Li R. Bernatchez JA, et al. J Med Chem. 2020 Jan 23;63(2):470-489. doi: 10.1021/acs.jmedchem.9b00775. Epub 2019 Oct 4. J Med Chem. 2020. PMID: 31549836 Review.
Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis.
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. Zhu Z, et al. Cell Stem Cell. 2020 Feb 6;26(2):187-204.e10. doi: 10.1016/j.stem.2019.11.016. Epub 2020 Jan 16. Cell Stem Cell. 2020. PMID: 31956038 Free PMC article.
Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Chenna BC, Li L, Mellott DM, Zhai X, Siqueira-Neto JL, Calvet Alvarez C, Bernatchez JA, Desormeaux E, Alvarez Hernandez E, Gomez J, McKerrow JH, Cruz-Reyes J, Meek TD. Chenna BC, et al. J Med Chem. 2020 Mar 26;63(6):3298-3316. doi: 10.1021/acs.jmedchem.9b02078. Epub 2020 Mar 17. J Med Chem. 2020. PMID: 32125159 Free PMC article.
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, Penn EC, Erath J, Rodriguez A, Sciotti RJ, Campbell RF, McKerrow J, Siqueira-Neto JL, Ferrins L, Pollastri MP. Singh B, et al. ACS Med Chem Lett. 2020 Jan 10;11(3):249-257. doi: 10.1021/acsmedchemlett.9b00453. eCollection 2020 Mar 12. ACS Med Chem Lett. 2020. PMID: 32184953 Free PMC article.
77 results