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Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies.
Andrade EL, Bento AF, Cavalli J, Oliveira SK, Schwanke RC, Siqueira JM, Freitas CS, Marcon R, Calixto JB. Andrade EL, et al. Among authors: siqueira jm. Braz J Med Biol Res. 2016 Dec 12;49(12):e5646. doi: 10.1590/1414-431X20165646. Braz J Med Biol Res. 2016. PMID: 27982281 Free PMC article. Review.
Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies.
Andrade EL, Bento AF, Cavalli J, Oliveira SK, Freitas CS, Marcon R, Schwanke RC, Siqueira JM, Calixto JB. Andrade EL, et al. Among authors: siqueira jm. Braz J Med Biol Res. 2016 Oct 24;49(11):e5644. doi: 10.1590/1414-431X20165644. Braz J Med Biol Res. 2016. PMID: 27783811 Free PMC article. Review.
Proanthocyanidin-rich fraction from Croton celtidifolius Baill confers neuroprotection in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine rat model of Parkinson's disease.
Moreira EL, Rial D, Aguiar AS Jr, Figueiredo CP, Siqueira JM, DalBó S, Horst H, de Oliveira J, Mancini G, dos Santos TS, Villarinho JG, Pinheiro FV, Marino-Neto J, Ferreira J, De Bem AF, Latini A, Pizzolatti MG, Ribeiro-do-Valle RM, Prediger RD. Moreira EL, et al. Among authors: siqueira jm. J Neural Transm (Vienna). 2010 Dec;117(12):1337-51. doi: 10.1007/s00702-010-0464-x. Epub 2010 Oct 8. J Neural Transm (Vienna). 2010. PMID: 20931248
Curcumin-loaded lipid and polymeric nanocapsules stabilized by nonionic surfactants: an in vitro and In vivo antitumor activity on B16-F10 melanoma and macrophage uptake comparative study.
Mazzarino L, Silva LF, Curta JC, Licínio MA, Costa A, Pacheco LK, Siqueira JM, Montanari J, Romero E, Assreuy J, Santos-Silva MC, Lemos-Senna E. Mazzarino L, et al. Among authors: siqueira jm. J Biomed Nanotechnol. 2011 Jun;7(3):406-14. doi: 10.1166/jbn.2011.1296. J Biomed Nanotechnol. 2011. PMID: 21830481
87 results