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Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities.
Harmon DB, Mandler WK, Sipula IJ, Dedousis N, Lewis SE, Eckels JT, Du J, Wang Y, Huckestein BR, Pagano PJ, Cifuentes-Pagano E, Homanics GE, Van't Erve TJ, Stefanovic-Racic M, Jurczak MJ, O'Doherty RM, Kelley EE. Harmon DB, et al. Among authors: sipula ij. Diabetes. 2019 Jun;68(6):1221-1229. doi: 10.2337/db18-1198. Epub 2019 Apr 1. Diabetes. 2019. PMID: 30936145 Free PMC article.
Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.
Belmonte FR, Dedousis N, Sipula I, Desai NA, Singhi AD, Chu Y, Zhang Y, Bannwarth S, Paquis-Flucklinger V, Harrington L, Shiva S, Jurczak MJ, O'Doherty RM, Kaufman BA. Belmonte FR, et al. PLoS One. 2019 May 28;14(5):e0203101. doi: 10.1371/journal.pone.0203101. eCollection 2019. PLoS One. 2019. PMID: 31136580 Free PMC article.
Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis.
Beppu LY, Mooli RGR, Qu X, Marrero GJ, Finley CA, Fooks AN, Mullen ZP, Frias AB Jr, Sipula I, Xie B, Helfrich KE, Watkins SC, Poholek AC, Ramakrishnan SK, Jurczak MJ, D'Cruz LM. Beppu LY, et al. JCI Insight. 2021 Feb 8;6(3):e140644. doi: 10.1172/jci.insight.140644. JCI Insight. 2021. PMID: 33351782 Free PMC article.
Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells.
Mooli RGR, Mukhi D, Pasupulati AK, Evers SS, Sipula IJ, Jurczak M, Seeley RJ, Shah YM, Ramakrishnan SK. Mooli RGR, et al. Among authors: sipula ij. Cell Mol Gastroenterol Hepatol. 2022;13(4):1057-1072. doi: 10.1016/j.jcmgh.2021.12.004. Epub 2021 Dec 11. Cell Mol Gastroenterol Hepatol. 2022. PMID: 34902628 Free PMC article.
Empagliflozin restores cardiac metabolic flexibility in diet-induced obese C57BL6/J mice.
Xie B, Ramirez W, Mills AM, Huckestein BR, Anderson M, Pangburn MM, Lang EY, Mullet SJ, Chuan BW, Guo L, Sipula I, O'Donnell CP, Wendell SG, Scott I, Jurczak MJ. Xie B, et al. Curr Res Physiol. 2022 May 28;5:232-239. doi: 10.1016/j.crphys.2022.05.003. eCollection 2022. Curr Res Physiol. 2022. PMID: 35677213 Free PMC article.
Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging.
Mau T, Lui LY, Distefano G, Kramer PA, Ramos SV, Toledo FGS, Santanasto AJ, Shankland EG, Marcinek DJ, Jurczak MJ, Sipula I, Bello FM, Duchowny KA, Molina AJA, Sparks LM, Goodpaster BH, Hepple RT, Kritchevsky SB, Newman AB, Cawthon PM, Cummings SR, Coen PM. Mau T, et al. J Gerontol A Biol Sci Med Sci. 2023 Aug 2;78(8):1367-1375. doi: 10.1093/gerona/glac238. J Gerontol A Biol Sci Med Sci. 2023. PMID: 36462195 Free PMC article.
30 results